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Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.

Finasteride may cause kidney damage.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

Finasteride negatively affects fish reproduction and gonadal development.

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Researchers developed a method to measure different forms of a drug that could help treat prostate issues and hair loss, and found how these forms behave in animals.

Testosterone increases muscle mass regardless of DHT conversion blocking.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Cinnamomi cortex may help treat prostate enlargement by reducing related proteins.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Compounds from Angelica koreana roots, especially osthenol, could be effective for treating conditions like prostate disease and hair loss.

New hybrid compound found to effectively prevent hair loss.

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

Glioblastoma cells can make androgens, which might help the tumor grow.

Gene variant linked to prostate cancer, hormone levels, and hair loss.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.

Korean and Caucasian men with male pattern baldness have different hair steroid levels.

New tests detect finasteride and dutasteride in urine quickly and easily.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

The herbal hair gel could be a safe hair growth treatment with minimal side effects.

Dendrobium officinale polysaccharide helps hair regrowth in hair loss mice by affecting local steroid metabolism and hair follicle responses.