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GlossaryStevens-Johnson syndrome

rare, severe skin reaction often triggered by medication or infection

Stevens-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes, often triggered by a reaction to medication or an infection. It typically begins with flu-like symptoms, followed by a painful red or purplish rash that spreads and blisters, leading to the top layer of skin dying and shedding. Immediate medical attention is crucial, as SJS can be life-threatening and requires hospitalization.

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Long-Term Complications of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: The Spectrum of Chronic Problems in Survivors Necessitates Multidisciplinary Follow-Up

research Long-term complications of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN): the spectrum of chronic problems in patients who survive an episode of SJS/TEN necessitates multidisciplinary follow-up

105 citations , February 2017 in “British Journal of Dermatology”

Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.

research Severe Physical Complications among Survivors of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

33 citations , October 2017 in “Drug Safety”

SJS/TEN survivors often have severe, overlooked long-term physical problems that are not properly treated after leaving the hospital.

research Minoxidil-Induced Stevens-Johnson Syndrome

15 citations , October 1981 in “Archives of internal medicine”

Minoxidil can cause severe skin reactions like Stevens-Johnson syndrome in rare cases.

research Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo

6 citations , January 2019 in “Dermatology Research and Practice”

Many survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo suffer long-term eye and skin problems.

research The chronic phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: beyond skin and eyes

October 2025 in “The Sri Lanka Journal of Dermatology”

SJS and TEN can cause long-term organ damage and psychological issues beyond skin and eye problems.

research Fatal Case of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Induced by Doxycycline or Flucloxacillin in a 77-Year-Old Woman: A Rare but Serious Adverse Drug Reaction

July 2025 in “Cureus”

Doxycycline or flucloxacillin can cause a rare, severe skin reaction that can be fatal, especially in the elderly.

research Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report

1 citations , January 2025 in “Therapeutic Advances in Drug Safety”

Antituberculosis drugs can cause severe skin reactions, requiring careful diagnosis and treatment.

Current Management of Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN)

research TATA LAKSANA TERKINI PENYAKIT SINDROM STEVENS-JOHNSON (SSJ)/ NEKROLISIS EPIDERMAL TOKSIK (NET)

July 2023 in “Media Dermato Venereologica Indonesiana”

Early diagnosis, stopping the suspected drug, and supportive care are crucial for treating Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

research Severe cutaneous adverse reactions to drugs

273 citations , May 2017 in “The Lancet”

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

research Drug-Induced Skin, Nail and Hair Disorders

114 citations , January 2007 in “Drug Safety”

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

research Identification of drug-specific public TCR driving severe cutaneous adverse reactions

88 citations , August 2019 in “Nature communications”

Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.

research Cutaneous effects of the most commonly used antidepressant medication, the selective serotonin reuptake inhibitors

55 citations , December 2006 in “Journal of The American Academy of Dermatology”

Antidepressants called SSRIs can cause skin problems, bleeding risk, and other side effects.

research Adverse Cutaneous Reactions to Mood Stabilizers

47 citations , January 2003 in “American Journal of Clinical Dermatology”

Mood stabilizers can cause serious skin reactions; careful monitoring and immediate treatment are crucial.

research Review of Fluconazole Properties and Analytical Methods for Its Determination

44 citations , April 2011 in “Critical reviews in analytical chemistry”

Fluconazole is an effective antifungal medication with potential side effects and lacks official analytical methods for its determination.

research Adverse Cutaneous Reactions to Antidepressants

44 citations , January 2002 in “American Journal of Clinical Dermatology”

Skin reactions to antidepressants are common but usually not serious and can be treated.

research The management of EGFR inhibitor adverse events: a case series and treatment paradigm

32 citations , January 2012 in “International Journal of Dermatology”

Skin side effects from EGFR inhibitor cancer treatment can be managed effectively, often without stopping the medication.

research Adverse Drug Reactions in HIV/AIDS Patients on Highly Active Antiretro Viral Therapy: A Review of Prevalence

24 citations , November 2023 in “NEWPORT INTERNATIONAL JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES”

ART for HIV/AIDS can cause side effects but is crucial for managing the infection.

research Anticonvulsant-Induced Cutaneous Reactions

18 citations , January 1999 in “CNS Drugs”

Some anticonvulsant drugs can cause skin reactions, ranging from mild to severe, and managing these reactions is important for patient care.

research Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

13 citations , March 2019 in “Pharmacology Research & Perspectives”

In Singapore, most skin reactions to drugs were in females and Chinese, often caused by painkillers, antibiotics, and some other drugs, with serious cases linked to genetics.

Cutaneous and Ocular Sequelae of Stevens-Johnson Syndrome and Lyell Syndrome

research Séquelles cutanéomuqueuses et oculaires des SJS et de Lyell

13 citations , December 2010 in “Annales de Dermatologie et de Vénéréologie”

The conclusion is that skin, mucous, and eye problems after Stevens-Johnson syndrome and Lyell syndrome significantly affect patients' lives, highlighting the need for comprehensive care and eye check-ups.

research Psychoactive drugs and skin

12 citations , June 2003 in “Journal of the European Academy of Dermatology and Venereology”

Some psychoactive drugs can cause skin reactions, with carbamazepine having a higher risk, and stopping the drug and seeing a dermatologist is important.

research Drug eruptions in dermatology

11 citations , June 2011 in “Expert Review of Dermatology”

Skin reactions to drugs are common and can be deadly, usually requiring stopping the drug and may be better prevented with genetic testing in the future.

research Cutaneous toxicities of new targeted cancer therapies: must know for diagnosis, management, and patient-proxy empowerment

7 citations , October 2019 in “Annals of palliative medicine”

New targeted cancer drugs can cause skin side effects, and managing them requires patient education and timely care.

Drug-Induced Skin Reactions: A Pathologist's Viewpoint

research Drug-induced skin reactions: a pathologist viewpoint

7 citations , June 2015 in “Cutaneous and Ocular Toxicology”

Some drugs can cause skin reactions, which may improve when the drug is stopped, and rapid diagnosis and stopping the drug is crucial.

research Adverse cutaneous effects of psychotropic medications

6 citations , October 2013 in “Expert Review of Dermatology”

Psychotropic medications can cause skin problems, including serious conditions, and patients should be monitored closely.

research Dermatologic Conditions of the Early Post-Transplant Period in Hematopoietic Stem Cell Transplant Recipients

5 citations , October 2018 in “American Journal of Clinical Dermatology”

Skin problems are common after stem cell transplants, and early treatment by dermatologists can improve patient outcomes.

research Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy

4 citations , January 2016 in “Dermatology Review”

Cancer treatments often cause skin, nail, and hair problems.

research Cutaneous Reactions to Drugs

3 citations , July 2017 in “Elsevier eBooks”

Skin reactions are a common reason for emergency visits due to drug allergies, with some severe cases needing intensive care.

research Topical imiquimod—Be aware of the unexpected

3 citations , April 2016 in “Journal of The American Academy of Dermatology”

A woman had a severe skin reaction from the drug imiquimod, used for skin cancer, highlighting the need for awareness of rare but serious side effects.

research The dermatology consultant: A retrospective analysis of inpatient dermatology

3 citations , May 2014 in “Journal of The American Academy of Dermatology”

Dermatologists greatly affect inpatient diagnosis and treatment of skin conditions, especially in spotting infections in patients with weakened immune systems.