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GlossarySubstance P

neuropeptide involved in pain perception and inflammation

Substance P (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator, playing a key role in pain perception by transmitting pain signals to the central nervous system. It is also involved in inflammatory processes and can influence hair growth by affecting the local immune response and blood flow in the scalp.

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Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

research Stress Inhibits Hair Growth in Mice by Induction of Premature Catagen Development and Deleterious Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations , March 2003 in “American Journal of Pathology”

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P

125 citations , September 2001 in “The FASEB Journal”

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

research Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice

76 citations , April 2013 in “PLoS ONE”

Chronic stress can cause hair loss by increasing oxidative stress, but antioxidants may help.

research Influence of substance-P on cultured sebocytes

46 citations , April 2008 in “Archives of Dermatological Research”

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

research Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

24 citations , April 2013 in “PLOS ONE”

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

research New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP₃‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75^NTRand TrkA) inex vivohuman male androgenetic scalp hair follicles

12 citations , April 2020 in “British Journal of Dermatology”

Caffeine may help reduce stress-induced hair loss.

Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle

research Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle

8 citations , May 2018 in “The Journal of Allergy and Clinical Immunology”

Activating the Nrf2 pathway reduces inflammation and cell activation in human hair follicles, suggesting a potential treatment for certain hair loss conditions.

research Substance P prolongs human hair growth in vitro

8 citations , September 2003 in “Journal of dermatological science”

Substance P helps hair grow longer and faster.

research Substance P in keratosis follicularis spinulosa decalvans

4 citations , September 2015 in “JAAD case reports”

Substance P may play a role in the inflammation seen in keratosis follicularis spinulosa decalvans.

Effects of Guasha on Histomorphology of Scraped Skin and Expression of Calcitonin Gene-Related Peptide and Substance P in Rats

research Effects of Guasha on histomorphology of scraped skins and on expression of calcitonin gene-related peptide and substance P in rats

3 citations , August 2018 in “Deleted Journal”

Guasha changed rat skin appearance and blood vessels temporarily without affecting certain nerve proteins or fiber structure.

research Effects of Substance P on the Expression of Various Factors to control Hair Growth in Human Hair Follicle Culture

1 citations , January 2004 in “Linchuang pifuke zazhi”

Substance P helps hair growth by extending the growth phase and affecting certain growth factors.

research Tissue and serum levels of substance P in trichodynia of androgenetic alopecia patients

January 2025 in “Journal of the Egyptian Womenʼs Dermatologic Society”

Higher substance P levels may cause discomfort in hair loss patients.

research 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation

July 2024 in “Journal of Investigative Dermatology”

Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.

A Novel Link Between Human Hair Follicle Neuroimmunology and Mitochondrial Biology: Substance P Increases Intrafollicular Oxidative Stress and Mitochondrial Biogenesis

research LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis

July 2022 in “Journal of Investigative Dermatology”

Substance P may contribute to hair loss by increasing oxidative stress and mitochondrial activity in hair follicles.

research Reduced rates of substance use disorder in patients with alopecia: An all of us case-control study

1 citations , June 2024 in “Archives of Dermatological Research”

Alopecia may lower the risk of substance use disorder.

Substances Declared as Active Ingredients in Topical Anti-Hair Loss Products: A Review of the Evidence for Their Effectiveness in Light of Clinical Studies

research Substances declared as active ingredients in topical anti-hair loss products – a review of the evidence for their effectiveness in light of clinical studies

June 2026 in “Homo Politicus (Academy of Humanities and Economics in Lodz)”

The effectiveness of ingredients in anti-hair loss products varies, and clinical trials are crucial to determine their success.

research Cutaneous manifestations associated with substance use disorders

April 2025 in “JAAD reviews.”

Skin issues can signal substance use, helping early detection and treatment.

research BIOACTIVE SUBSTANCE OF MEDICINAL PLANTS EFFECTIVE AGAINST HAIR LOSS

January 2025 in “International Journal of Biological Innovations”

Medicinal plant substances can help prevent hair loss and improve hair health.

research Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp

5 citations , October 1988 in “Clinics in Dermatology”

Minoxidil promotes hair growth but exact mechanism is unknown.

research The synergistic effect of phototherapy and active substances on hair growth

August 2024 in “Journal of Photochemistry and Photobiology B Biology”

Combining light therapy with certain substances improves hair growth in people with hair loss.

Associations Of Prenatal And Postnatal Exposure To Perfluoroalkyl Substances With Pubertal Development And Reproductive Hormones In Females And Males: The Home Study

research Associations of prenatal and postnatal exposure to perfluoroalkyl substances with pubertal development and reproductive hormones in females and males: The HOME study

5 citations , May 2023 in “Science of the total environment”

PFAS exposure in adolescence may delay puberty in females.

research Prenatal and prepubertal exposures to organochlorine compounds and perfluoroalkyl substances and pubertal development at age 12: The PELAGIE cohort study

October 2025 in “Environment International”

Exposure to certain chemicals before birth and during childhood may affect puberty timing.

research Extractable substances from human hair: a discussion about the origin of the holes

15 citations , October 2004 in “Colloids and surfaces. B, Biointerfaces”

Holes in mature hair are likely caused by the removal of substances during hair care.

A Fast and Efficient UPLC-ESI-MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts for Preventing Hair Loss

research A Fast and Efficient UPLC-ESI-MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss

4 citations , September 2015 in “Bulletin of the Korean Chemical Society”

Researchers developed a quick and sensitive method to identify and measure hair growth-promoting substances in a herbal mix.

research Significance of the follicular pathway for dermal substance penetration quantified by laser Doppler flowmetry

10 citations , August 2015 in “Journal of biophotonics”

Hair follicles help substances penetrate the skin faster and more effectively.

research Immunochemical studies on blood group A substance from human hair

6 citations , November 1977 in “International Journal of Legal Medicine”

Human hair contains a substance that shows blood group A activity.

Effect of Iodine-Deficient Diets and Goitrogenic Substances on the Weight Growth of Wistar Rats

research Effet de la consommation de régimes carencés en iode ou contenant de substances goitrigènes ou supposées sur la croissance pondérale de rats Wistar

1 citations , August 2022 in “International journal of biological and chemical sciences”

Iodine-deficient diets and antithyroid substances affected rat growth and behavior, but most adapted with positive weight gain.

Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration

research Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration

September 2025 in “Drug Design Development and Therapy”

Combining platelet-rich products, biomaterials, and bioactive substances may improve skin treatment, but more research is needed.

research Emulsion formulation assays based on natural substances stimulating the hair growth and evaluation of its biological activity

June 2021 in “Zenodo (CERN European Organization for Nuclear Research)”

Natural substance emulsions can effectively stimulate hair growth.

research The effects of common house fly (Musca domestica) larvaederived substances on wound healing in mouse model

1 citations , December 2022 in “Parasitologists United Journal”

House fly larvae substances improve wound healing and skin regeneration, especially in immunosuppressed mice.