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A young patient with unusual insulin resistance and high testosterone levels had a rare INSR gene mutation.

Dapagliflozin helps protect heart cells under stress by improving mitochondrial function and reducing cell damage.

The drug showed promise in treating renal cell carcinoma with manageable side effects.

Lifestyle changes are more effective than medication for reducing type 2 diabetes risk.

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

Urotensin II increases growth and VEGF production in rat skin cells by turning on the Wnt-β-catenin pathway.

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

Lifestyle changes are more effective than metformin for reducing type 2 diabetes risk.

Selumetinib effectively reduces tumor size in many children with neurofibromatosis type 1, but can cause skin and hair issues.

Metformin and liraglutide improved symptoms of HAIR-AN syndrome in a child.

Pemigatinib may be effective for treating ZMYM2::FGFR1 fusion-positive leukemia.

Some synthetic carbohydrate receptors, especially compounds 3 and 15, show strong potential for treating Zika virus.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

The drug BAY 1158061 is safe, well-tolerated, and shows potential for treating diseases related to prolactin.

Weight-loss drugs are not linked to suicidal thoughts.

Topical glycopyrrolate lotion helped reduce excessive sweating from eating in a diabetic man.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Lifestyle changes are more effective than medication for reducing type 2 diabetes risk.

Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.

CYLD deficiency in skin tumors disrupts hair follicle cell processes and protein secretion.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

A woman's severe insulin resistance improved with treatment, but she still had high testosterone levels due to ovarian issues.

There's no significant link between the D19S884 marker at the insulin receptor gene and polycystic ovary syndrome.

Yuperio combined with bisoprolol improves heart function in patients with dilated cardiomyopathy.