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A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.

Dietary L-serine supplementation can reduce symptoms of HSAN1 by lowering harmful 1-deoxySL levels.

Diabetic neuropathy in mice is linked to poor mitochondria function and lower brain hormone production.

The HtrA1L364P mutation causes brain dysfunction and blood vessel damage.

Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.

Injecting newborn mice with a niacin blocker caused skin, gut, and brain damage similar to human pellagra.

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

2-DG reduces seizures by enhancing brain inhibition through specific receptor activation.

The patient's hair had unique damage and a lower sulfur-to-nitrogen ratio compared to relatives, but not compared to healthy controls.

Removing certain brain receptors in mice worsens seizure severity and response to treatment during hormone withdrawal.

Researchers found a specific T cell receptor linked to severe drug reactions like Stevens-Johnson syndrome when patients take carbamazepine.

Neurosteroids may help prevent seizures in epilepsy.

Neurosteroids and benzodiazepines reduce neuron excitability, with lasting effects on inhibitory neurons.

Glycine is a key transmitter in rat spinal cord synapses, often alongside GABA.

Thallium poisoning can cause worsening nerve damage and vision loss without typical symptoms.

14,15-EET may help reduce poststroke pain by affecting certain brain proteins.

Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.

Memantine may slightly improve memory in people with Down syndrome, but more research is needed.

Increasing neurotrophin 4 in skin boosts nerve endings but not sensory neuron count.

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

Stress increases neurosteroids that help prevent seizures.

Psychotropic medications can cause skin problems, including serious conditions, and patients should be monitored closely.

Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.

If someone has unexplained nerve pain and hair loss, doctors should check for thallium poisoning.