July 2003 in “Journal of Cutaneous Medicine and Surgery” High blood pressure drugs often cause skin lupus, stopping the drug usually helps. A vaccine helps prevent genital herpes and HPV-16. More frequent light therapy clears psoriasis faster. No link was found between low iron and chronic hair loss.
December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)” AKR1C3 could be a treatment target for metabolic issues in PCOS.
165 citations
,
October 2013 in “Nature Communications” Scientists made working salivary glands in mice using bioengineered cells, which could help treat dry mouth.
151 citations
,
July 2011 in “Archives of Dermatological Research” Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.
99 citations
,
August 2009 in “Nature Genetics” Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.
85 citations
,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
81 citations
,
November 2012 in “Journal of the National Cancer Institute” The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.
81 citations
,
January 2006 in “Journal of cellular physiology” Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.
73 citations
,
March 2017 in “Scientific Reports” Bioengineered tooth germ can restore whole teeth in dogs.
58 citations
,
March 2019 in “Experimental Dermatology” Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
48 citations
,
December 2004 in “Differentiation” Tooth papilla cells can help regenerate hair follicles and grow hair.
40 citations
,
October 2002 in “Endocrinology” Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.
28 citations
,
September 2015 in “Wiener Klinische Wochenschrift” New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.
28 citations
,
September 2013 in “Journal of Investigative Dermatology” The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.
27 citations
,
May 2006 in “Biochemical and Biophysical Research Communications” Wnt-10b is important for starting hair growth and developing hair follicles.
25 citations
,
September 2006 in “Birth Defects Research” Different processes create patterns in skin and things like hair and feathers.
19 citations
,
January 2018 in “BioMed Research International” miR-195-5p reduces hair growth ability in cells by blocking a specific growth signal.
19 citations
,
March 2017 in “PLoS ONE” PSU are better than THF at regenerating skin layers in lab models.
16 citations
,
December 2019 in “Journal of Cellular and Molecular Medicine” Sonicated platelet-rich plasma boosts hair growth by activating stem cells.
15 citations
,
September 2014 in “Journal of The American Academy of Dermatology” Seven patients were misdiagnosed with discoid lupus instead of lichen planopilaris due to similar symptoms, showing the need for careful diagnosis in scarring hair loss conditions.
14 citations
,
January 2021 in “Scientific Reports” Using micro skin tissue columns improves skin wound healing and reduces scarring.
13 citations
,
January 2020 in “Experimental Dermatology” PRP growth factor concentrations vary, no significant hair growth difference found.
13 citations
,
July 2019 in “Journal of Dermatological Science” Increasing alkaline phosphatase in human skin cells helps to grow more hair.
7 citations
,
February 1998 in “Polymer journal” Keratin structure in hair is stable at pH 5-6 but disrupts between pH 6-7.
4 citations
,
May 2018 in “Journal of Neuro-Ophthalmology” New treatments for relapsing multiple sclerosis are more effective and convenient but have higher risks of serious side effects.
4 citations
,
January 2004 in “Biological and Pharmaceutical Bulletin” AgK114 protein helps in hamster skin injury recovery.
3 citations
,
February 2021 in “Experimental dermatology” Dermal papilla microtissues could be useful for initial hair growth drug testing.
2 citations
,
January 2020 in “Methods in molecular biology” Scientists created early-stage hair follicles from human skin cells, which could help treat baldness and study hair growth.
1 citations
,
January 2019 in “Annals of dermatology/Annals of Dermatology” STAT5 is crucial for hair growth in 3D cultured human dermal papilla cells.
Finding functions for unknown GPCRs is hard but key for making new drugs.