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Natural Product Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration

research Natural product Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration

May 2023 in “Research Square (Research Square)”

Shi-Bi-Man activates hair follicle stem cells and promotes hair growth by changing lactic acid metabolism and other cellular processes.

research Alteration of serum and tissue tumor necrosis factor alpha levels: A possible mechanism of action of oral pulse steroids in the treatment of alopecia areata

5 citations , October 2018 in “Journal of Cosmetic Dermatology”

Oral pulse steroids reduce TNF-α levels, improving alopecia areata.

No Evidence for THAP1/DYT6 Variants as Disease Modifiers in DYT1 Dystonia

research No evidence for THAP1i>/DYT6i> variants as disease modifiers in DYT1 dystonia

10 citations , June 2011 in “Movement Disorders”

THAP1 gene changes do not affect DYT1 dystonia; finasteride may help reduce tics and OCD in Tourette syndrome.

research Influence of FHITi> on benzo[ ai> ]pyrene-induced tumors and alopecia in mice: Chemoprevention by budesonide and Ni> -acetylcysteine
24 citations , May 2006 in “Proceedings of the National Academy of Sciences of the United States of America”

Budesonide and N-acetylcysteine reduced tumors and alopecia in mice, regardless of FHIT gene status.

research Ritlecitinib in Alopecia Areata: A 24‐Week Real‐World Experience Contrasting JAK Inhibitor‐Naïve and JAK Inhibitor‐Experienced Patients
December 2025 in “The Journal of Dermatology”

Ritlecitinib effectively reduces hair loss in JAK inhibitor-naïve alopecia areata patients.

research 805 Topical thyroid hormones promote hair follicle and epithelial hair follicle stem cell growth in intact human scalp skin ex vivo
July 2024 in “Journal of Investigative Dermatology”

Topical thyroid hormones may boost hair growth.

research Efficacy and Safety of Ritlecitinib in Alopecia Areata: A Systematic Review and Meta-Analysis (Preprint)
July 2024

Ritlecitinib improves hair regrowth in alopecia areata without increasing adverse risks.

research A case of hyperpigmentation and acanthosis nigricans by testosterone injections
6 citations , February 2014 in “Human & experimental toxicology”

Testosterone injections can cause skin darkening and thickening.

research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors
20 citations , March 2005 in “Current Medicinal Chemistry”

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

research JAK kinase pathway inhibitor drugs in patients with moderate-to-severe alopecia: a real-world experience
May 2024 in “e_Buah”

research 640 Exploring the synergic effects of a plant and a peptide on hair follicle pigmentation
July 2022 in “Journal of Investigative Dermatology”

The combination of a plant extract and a peptide can increase hair pigmentation and may reverse greying.

research 1108 Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

A PTH-based treatment improved hair regrowth better than ruxolitinib in a mouse model of hair loss.

research 420 Severe thiopurine-induced myelotoxicity and hair loss in Japanese patients with NUDT15 gene variant: A retrospective case-control study
April 2018 in “Journal of Investigative Dermatology”

Screening for the NUDT15 gene variant can prevent severe side effects from thiopurine drugs in East-Asian people.

research Effects of Taxifolin-3-O-arabinopyranoside from Rhododendron mucronulatum Root Extracts on the Alleviation of Hair-Loss Symptoms
June 2024 in “Korean Journal of Pharmacognosy”

The compound from Rhododendron mucronulatum roots may help treat male pattern hair loss.

research A Phase I Study of Topical Tempol for the Prevention of Alopecia Induced by Whole Brain Radiotherapy
131 citations , October 2004 in “Clinical Cancer Research”

Tempol is safe and may prevent hair loss from brain radiotherapy.

research Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODCi> Transgenic Mice
48 citations , June 2000 in “Japanese Journal of Cancer Research”

Dimethylarsinic acid speeds up skin tumor growth in certain mice.

research Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling
March 2023 in “Natural product sciences”

Celtis choseniana may help treat hair loss by reducing androgen effects and boosting hair growth signals.

research 加齢性白質病変(leukoaraiosis)update (特集あしたの脳梗塞)
July 2013 in “Brain and nerve : 神経研究の進歩”

P chinensis may help treat stress-related hair loss.

research The usefulness and wellbeing of Tofacitinib in the treatment of Alopecia Areata
October 2022 in “Journal of Armed Forces Medical College, Bangladesh”

Tofacitinib is effective and safe for treating alopecia areata.

research A Preliminary Study on the Effect of Biochanin A on the Hair Growth of Testosterone-induced Alopecia Mice
1 citations , January 2014

Biochanin A promotes hair growth in mice with testosterone-induced hair loss.

research Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia
7 citations , January 2018 in “Medicinski arhiv”

A herbal extract may help treat certain types of hair loss by reducing a specific gene's activity.

research Polymer conjugated retinoids for controlled transdermal delivery
36 citations , July 2017 in “Journal of controlled release”

A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with fewer side effects.

research 563 CsA-induced hypertrichosis might be caused in part by inhibition of TGF-β2 expression in dermal papilla cells.
November 2022 in “Journal of Investigative Dermatology”

The medicine Cyclosporin A might cause excessive hair growth by reducing a protein that controls hair growth.

research Omega 3 fatty acid-enriched nanoemulsion of thiocolchicoside for transdermal delivery: formulation, characterization and absorption studies
29 citations , June 2014 in “Drug delivery”

The new formulation improved the skin absorption of the drug Thiocolchicoside.

research 0935 Unravelling the role of JAK3/TEC kinase signalling with ritlecitinib in alopecia areata lesional skin and alopecia areata-induced human hair follicles ex vivo
July 2025 in “Journal of Investigative Dermatology”

Ritlecitinib reduces alopecia areata symptoms by blocking JAK3/TEC signaling and T-cell activity.

research T-Cell Reconstitution after Thymus Xenotransplantation Induces Hair Depigmentation and Loss
7 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

T-cell reconstitution after thymus transplantation can cause hair whitening and loss.

research Topically applied thyroid hormones stimulate hair growth in organ-cultured human scalp skin
June 2024

Applying thyroid hormones to the scalp can help hair grow.

research Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?
9 citations , July 2020 in “Experimental Dermatology”

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

research Non-pigmentary actions of alpha-melanocyte-stimulating hormone--lessons from the cutaneous melanocortin system.
16 citations , May 2006 in “PubMed”

Alpha-melanocyte-stimulating hormone helps manage skin inflammation and protect against UV damage.

research Adverse cutaneous reactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia
25 citations , November 2013 in “Journal of the American Academy of Dermatology”

Many patients on new leukemia drugs had mild to moderate skin reactions.

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research Natural product Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration

research Alteration of serum and tissue tumor necrosis factor alpha levels: A possible mechanism of action of oral pulse steroids in the treatment of alopecia areata

research No evidence for THAP1i>/DYT6i> variants as disease modifiers in DYT1 dystonia

research Influence of FHITi> on benzo[ ai> ]pyrene-induced tumors and alopecia in mice: Chemoprevention by budesonide and Ni> -acetylcysteine

research Ritlecitinib in Alopecia Areata: A 24‐Week Real‐World Experience Contrasting JAK Inhibitor‐Naïve and JAK Inhibitor‐Experienced Patients

research 805 Topical thyroid hormones promote hair follicle and epithelial hair follicle stem cell growth in intact human scalp skin ex vivo

research Efficacy and Safety of Ritlecitinib in Alopecia Areata: A Systematic Review and Meta-Analysis (Preprint)

research A case of hyperpigmentation and acanthosis nigricans by testosterone injections

research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors

research JAK kinase pathway inhibitor drugs in patients with moderate-to-severe alopecia: a real-world experience

research 640 Exploring the synergic effects of a plant and a peptide on hair follicle pigmentation

research 1108 Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata

research 420 Severe thiopurine-induced myelotoxicity and hair loss in Japanese patients with NUDT15 gene variant: A retrospective case-control study

research Effects of Taxifolin-3-O-arabinopyranoside from Rhododendron mucronulatum Root Extracts on the Alleviation of Hair-Loss Symptoms

research A Phase I Study of Topical Tempol for the Prevention of Alopecia Induced by Whole Brain Radiotherapy

research Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODCi> Transgenic Mice

research Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling

research 加齢性白質病変(leukoaraiosis)update (特集あしたの脳梗塞)

research The usefulness and wellbeing of Tofacitinib in the treatment of Alopecia Areata

research A Preliminary Study on the Effect of Biochanin A on the Hair Growth of Testosterone-induced Alopecia Mice

research Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

research Polymer conjugated retinoids for controlled transdermal delivery

research 563 CsA-induced hypertrichosis might be caused in part by inhibition of TGF-β2 expression in dermal papilla cells.

research Omega 3 fatty acid-enriched nanoemulsion of thiocolchicoside for transdermal delivery: formulation, characterization and absorption studies

research 0935 Unravelling the role of JAK3/TEC kinase signalling with ritlecitinib in alopecia areata lesional skin and alopecia areata-induced human hair follicles ex vivo

research T-Cell Reconstitution after Thymus Xenotransplantation Induces Hair Depigmentation and Loss

research Topically applied thyroid hormones stimulate hair growth in organ-cultured human scalp skin

research Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

research Non-pigmentary actions of alpha-melanocyte-stimulating hormone--lessons from the cutaneous melanocortin system.

research Adverse cutaneous reactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia