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May 2015 in “Experimental Dermatology” Overactive Stat3 in mouse skin causes hair loss and cell structure damage.
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October 2014 in “International Journal of Molecular Sciences” Tanshinone IIA helps protect tissue from low oxygen damage by activating certain cell pathways.
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January 2012 in “International Food Research Journal” Tofacitinib effectively treated a woman's severe symptoms from a rare autoimmune condition.
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April 2012 in “Journal of Investigative Dermatology” KRTAP2 genes are crucial for hair structure and may impact hair disorders and treatments.
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January 2006 in “International review of cytology” Keratin-associated proteins are crucial for hair strength and structure.
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October 2023 in “Clinical, cosmetic and investigational dermatology” Tofacitinib improved hair loss and skin symptoms in a patient after secukinumab caused hair loss.
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November 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Cystatin M/E helps in the final stages of hair and nail formation by controlling certain enzymes.
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December 2015 in “Journal of Investigative Dermatology” The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.
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March 2024 in “iScience” Long-lived proteins may predict age-related diseases.
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January 2013 in “MedChemComm” PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.
November 2022 in “Scientific Data” The research identified genes and non-coding RNAs in cells that could be affected by testosterone, which may help understand hair loss and prostate cancer.
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May 2014 in “BMC medical genetics” A woman with a unique syndrome similar to TRPS has a genetic change near the TRPS1 gene, affecting its regulation.
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September 2018 in “Acta histochemica” The mTOR pathway proteins are altered in the hair follicles of patients with Lichen Planopilaris and Frontal Fibrosing Alopecia.
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April 2016 in “Journal of Investigative Dermatology” STAT5 activation is crucial for starting the hair growth phase.
January 2022 in “Skin Pharmacology and Physiology” Higher STAT3 levels are found in hair loss areas, but not linked to hair loss severity.
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January 2024 in “Annals of Dermatology” Dickkopf-related Protein 2 can help hair grow by activating a specific cell pathway.
April 2026 in “Proceedings of the National Academy of Sciences” The study identifies Tmem30b as a crucial regulator in outer hair cells (OHCs) for hearing, highlighting its role in maintaining the structure of hair bundles in the cochlea. Tmem30b, a phospholipid-flippase chaperone, initially localizes to the nuclear membrane and later stabilizes in the stereocilia and cuticular plate. Tmem30b −/− mice show early-onset hearing loss due to disorganized OHC stereocilia, starting at P7. Tmem30b partners with Atp8b1 to regulate phospholipid asymmetry, and disruption of this complex destabilizes OHC bundles. AAV-mediated delivery of Tmem30b to hair cells corrects stereocilia defects in Tmem30b −/− and Atp8b1 −/− mice, and overexpression of Tmem30b protects against noise-induced and aminoglycoside-induced hearing loss. The findings suggest Tmem30b–Atp8b1–mediated lipid regulation as a potential therapeutic target for hearing loss.
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Sox13 is a marker for early hair follicle development but not essential for skin and hair growth.
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July 2016 in “Medicine” Wnt/β-catenin and TGF-β pathways affect hair loss, and activating Wnt/β-catenin could be a potential treatment.
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