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Tofacitinib effectively treated a woman's complex autoimmune and autoinflammatory disorders.

Cathepsin L is essential for normal hair growth and development.

Topical PROTACs show promise for treating skin conditions but need better stability and delivery methods.

Translation levels actively determine keratinocyte cell fate.

SOX11 and SOX4 help skin cells act like embryonic cells to heal wounds in mice.

KRT17 may be a new target for endometrial cancer treatment because it helps cancer cells move and form new blood vessels.

Mutations in the KRT16 gene can cause skin and nail disorders.

EGF affects hair and skin development.

KRTAP genes evolved early in mammals, leading to diverse hair traits.

Human TMEM2 does not break down hyaluronan but helps control its metabolism.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

Lack of cystatin M/E causes thin hair and dry skin.

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

Increased Stat3 activity reduces hair follicle stem cells and boosts other stem/progenitor cells.

Compounds from Alpinia zerumbet may help with hair regrowth and cancer treatment by targeting PAK1.

Blocking the JAK/STAT pathway may help reduce skin sensitivity in Xeroderma pigmentosum.

Wnt signaling is vital for cell growth, development, and cancer research.

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

The KRTAP7-1 gene is very similar across different cattle and yak breeds and likely plays a role in hair strength and shape.

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

CTIP2 may help in skin development and maintenance.

Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.

Blocking JAK1 or JAK3 helps reverse hair loss in a mouse model of alopecia areata.

Patched1 helps prevent tumors by controlling cell growth.

A pathway helps maintain long telomeres in both stem and cancer cells.

MITF+ melanoma patients are more likely to have multiple melanomas and unique skin patterns.

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

Keloid skin disorder involves abnormal fibroblast activation and immune response, linked to a group of genes including FGF11.

Mutations in keratin genes cause skin disorders, but new treatments show promise.