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GlossaryTelogen Hair Follicles

resting phase of the hair growth cycle

Telogen hair follicles are hair follicles in the resting phase of the hair growth cycle. During this phase, which typically lasts around 2-3 months, the hair is not actively growing and is eventually shed to make way for new hair growth. This is a normal part of the hair cycle, and about 10-15% of all hair follicles are in the telogen phase at any given time.

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Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P

125 citations , September 2001 in “The FASEB Journal”

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

research A technique for more precise distinction between catagen and telogen human hair follicles ex vivo

9 citations , February 2018 in “Journal of The American Academy of Dermatology”

Researchers developed a new method using methylene blue staining to more accurately identify the growth stage of human hair follicles.

research FGF18 signaling determines radioresistance of telogen hair follicles by the arrest of hair cycling

September 2016 in “Journal of dermatological science”

FGF18 helps hair follicles resist radiation by stopping hair growth cycles.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

6 citations , November 2013 in “International Journal of Radiation Biology”

Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.

research Transcriptomic analysis reveals critical genes for the hair follicle of Inner Mongolia cashmere goat from catagen to telogen

25 citations , October 2018 in “PloS one”

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

research Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

24 citations , May 2022 in “BMC Veterinary Research”

lncRNAs play a key role in hair follicle development, affecting cashmere quality and yield.

research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

November 2013 in “Institutional Repositories DataBase (IRDB)”

Gamma-ray exposure during hair rest phase harms hair growth and color in mice.

research Hair Follicles of Anterior Parietal Region are More Vulnerable than Occipital Region in Classic Acute Telogen Effluvium

1 citations , January 2003 in “Annals of Dermatology”

Hair in the front part of the scalp is more likely to fall out than hair in the back in acute telogen effluvium.

Effects of Platelet-Rich Plasma on Hair Follicle Count and Hair Ratios in Androgenic Alopecia: Alone or Combined with Other Treatments

research Effects of platelet-rich plasma application on hair follicle count, telogen/anagen ratio, and miniaturized hair ratio in patients with androgenic alopecia: alone or in combination with other treatments

July 2025 in “Journal of Dermatological Treatment”

PRP improves hair growth in androgenic alopecia, especially when combined with minoxidil.

research The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles

35 citations , February 2019 in “Cell Communication and Signaling”

BMP6 and Wnt10b control whether hair follicles are resting or growing.

research Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo

25 citations , June 2004 in “Journal of Investigative Dermatology”

Macrophage-stimulating protein helps hair grow and can start hair growth phase in mice and human hair samples.

research Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

7 citations , August 2020 in “Genes”

Different genes are active in dogs' hair growth and skin, similar to humans, which helps understand dog skin and hair diseases and can relate to human conditions.

research Transcriptomic analysis of regulatory mechanisms in the telogen-anagen transition of ovine hair follicles

2 citations , December 2024 in “BMC Genomics”

Key genes and pathways control sheep hair growth phases.

The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma

research The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma

October 2024 in “Experimental Dermatology”

The belief about hair shedding phases is likely incorrect and needs reevaluation.

Claudin-1 and Claudin-3 Maintain Proper Hair Follicle Structure and Regulate Telogen Effluvium

research 1319 Claudin-1 and -3 maintain proper hair follicle structure and regulate telogen effluvium

April 2018 in “Journal of Investigative Dermatology”

Claudin-1 and Claudin-3 are crucial for keeping hair follicle structure and preventing a type of hair loss called telogen effluvium.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice

113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

research The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

13 citations , September 2018 in “Scientific Reports”

The research found that a complex gene network, controlled by microRNAs, is important for hair growth in cashmere goats.

research Ex vivo detection of SARS CoV 2 spike protein in human hair follicles and potential link to telogen effluvium

November 2025 in “Scientific Reports”

COVID-19 may cause hair loss by affecting hair follicles.

research Impact of Consciousness Energy Healing Treatment on the Telogen Skin of Hair Follicles of C57BL/6 Mice

December 2018 in “viXra”

Biofield Energy Healing may help hair growth and skin health.

research Adenovirus-Mediated Wnt5a Expression Inhibits the Telogen-To-Anagen Transition of Hair Follicles in Mice

19 citations , January 2013 in “International journal of medical sciences”

Increasing Wnt5a in mice skin delays hair growth but doesn't stop it.

research Expression of E6 and E7 papillomavirus oncogenes in the outer root sheath of hair follicles extends the growth phase and bypasses resting at telogen.

10 citations , October 2000 in “PubMed”

E6/E7 oncogenes in hair follicles cause continuous hair growth by skipping the resting phase.

Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models

research Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models

April 2021 in “Current Topics in Nutraceutical Research”

Citron seed oil may help prevent or treat hair loss by promoting hair growth and increasing hair density.

A Randomized Study of Biomimetic Peptides Efficacy and Impact on the Growth Factors Expression in the Hair Follicles of Patients with Telogen Effluvium

research A Randomized Study of Biomimetic Peptides Efficacy and Impact on the Growth Factors Expression in the Hair Follicles of Patients with Telogen Effluvium

January 2018 in “journal of applied pharmaceutical science”

Biomimetic peptides improved hair growth and increased growth factors in hair follicles for hair loss patients.

research Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice

June 2017 in “Experimental and Therapeutic Medicine”

The anti-CXCL4 antibody helps mice grow hair faster and prevents hair loss.

The Role of Hair Follicle Counts and Ratios in the Histopathological Assessment of Androgenic Alopecia, Alopecia Areata and Telogen Effluvium: Does Counting 'Count'?

research THE ROLE OF HAIR FOLLICLE COUNTS AND RATIOS IN THE HISTOPATHOLOGICAL ASSESSMENT OF ANDROGENIC ALOPECIA, ALOPECIA AREATA AND TELOGEN EFFLUVIUM: DOES COUNTING ‘COUNT’?

March 2023 in “Human Pathology”

Hair follicle counts and ratios are helpful in diagnosing hair loss types, but should be used with other specific features for accurate diagnosis.

research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

Estrogen affects hair growth and skin cell multiplication.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research Temporary hair removal by low fluence photoepilation: Histological study on biopsies and cultured human hair follicles

134 citations , September 2008 in “Lasers in surgery and medicine”

Low fluence photoepilation temporarily removes hair by targeting the hair follicle's pigmented area without severe damage.

research Epithelial skirt and bulge of human facial vellus hair follicles and and associated Merkel cell-nerve complex

48 citations , July 1993 in “Archives of Dermatological Research”

Merkel cells are abundant in facial vellus hair follicles, especially during the anagen phase.

Histopathological Insights Into Hair Loss in Cronkhite-Canada Syndrome: Diffuse Anagen-Telogen Conversion Precedes Clinical Hair Loss Progression

research Histopathological insights into hair loss in Cronkhite-Canada syndrome: Diffuse anagen-telogen conversion precedes clinical hair loss progression

16 citations , May 2013 in “Australasian Journal of Dermatology”

Hair loss in Cronkhite-Canada syndrome is reversible by treating the gut issues and doesn't need steroid treatment for the hair itself.