82 citations
,
February 1989 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.
47 citations
,
January 2001 in “Journal of Investigative Dermatology” High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.
January 2020 in “Journal of Men s Health” The combination treatment reduced prostate size and improved testosterone deficiency symptoms but was less effective for sexual function.
72 citations
,
April 2008 in “The Journal of urology/The journal of urology” Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.
September 2006 in “Data Archiving and Networked Services (DANS)” Understanding testosterone and estradiol levels is crucial for identifying normal and abnormal hormone levels in men, especially as they age.
15 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” 5α-Reductase inhibitors can negatively affect male sexual function and, in some cases, significantly reduce sperm count, but these effects may be reversible.
June 2023 in “Journal of personalized medicine” Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.
31 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.
March 2024 in “The journal of sexual medicine” The therapies improved ejaculation disorders and sexual function in middle-aged men.
Finasteride reduces prostate size and PSA levels in young patients.
1 citations
,
October 2024 in “JCEM Case Reports” 5α-reductase deficiency can cause ambiguous genitalia and gender dysphoria, treatable with testosterone.
Finasteride reduces blood vessel formation in seminal vesicles.
18 citations
,
June 2016 in “PeerJ” Testosterone increases certain kidney protein levels, potentially raising blood pressure.
April 2017 in “The journal of sexual medicine” 5-alpha-reductase inhibitors significantly affect the penile tissue of hypertensive rats.
4 citations
,
December 2014 in “PubMed” Pre-operative hormone treatment for hypospadias surgery might improve outcomes, but more research is needed to confirm.
9 citations
,
January 2017 in “Archives of biochemistry and biophysics” Testosterone raises blood pressure and changes kidney protein levels.
14 citations
,
March 2001 in “Psychiatric Services” Older men should openly discuss sexual health with doctors to improve their quality of life.
12 citations
,
January 1998 in “Drug safety” Finasteride helps reduce prostate size and symptoms in BPH but is less effective than terazosin and works best for larger prostates.
129 citations
,
February 2006 in “Andrology” Men with low testosterone should be carefully evaluated and monitored before and during treatment.
2 citations
,
August 2021 in “The Journal of Urology” The procedure involving seminal vesiculoscopy, TURED, and balloon dilation effectively treated a man's hematospermia and improved his dysorgasmia.
1 citations
,
August 2024 in “PubMed” Zhuangyao Jianshen pill reduces prostate enlargement and inflammation in rats.
23 citations
,
July 2015 in “The Journal of Membrane Biology” Testosterone increases certain proteins in the uterus, reducing fluid volume.
Finasteride reduces prostate size and DHT in male mastomys but not in females.
November 2017 in “International journal of family & community medicine” A man's low testosterone and related symptoms improved after he stopped taking hair loss drugs.
39 citations
,
January 2019 in “The World Journal of Men's Health” Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.
October 2010 in “Journal of Men's Health” The conclusion is that doctors should be careful when prescribing 5α-reductase inhibitors due to possible serious side effects, and they should discuss these risks with patients.
January 2007 in “Annals of The Royal College of Surgeons of England” Removing a hormone-producing adrenal tumor can stop hair loss in women with high testosterone levels.
280 citations
,
May 2005 in “Andrology” Testosterone treatment for older men can have short-term benefits, but long-term risks are unclear, requiring careful evaluation and monitoring.
8 citations
,
August 2018 in “Turkish journal of urology” Hair wrapped tightly around a boy's penis can cause serious damage if not treated quickly.