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research Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells
The study created a mouse model to better understand hair follicle stem cells' role in hair growth and repair.
research The Distribution of Preputial Vessels at Different Severity of Rat Congenital Hypospadias Model
Micro-CT helps identify suitable areas for surgical procedures based on blood vessel distribution in hypospadias-affected rats.
research Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold
The 3D scaffold helped maintain hair cell traits and could improve hair loss treatments.
research Mitotic activity in the epidermis of the rabbit stimulated with local applications of testosterone propionate
Testosterone applied to rabbit skin increases skin cell growth and changes skin structure.
research Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin
Ovine hair follicle stem cells can regenerate haired skin and may improve wool production.
research Incorporation of hair follicles in 3D bioprinted models of human skin
3D bioprinting can now create skin with hair-like structures for medical use.
research In vitro culture of murine fetal epidermal stem cell and its relationship with the regeneration of hair follicle
Murine fetal epidermal stem cells can help regenerate hair follicles.
research Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering
Biomimetic scaffolds are better than traditional methods for growing cells and could help regenerate various tissues.
research 877 Small T antigen from a folliculotropic polyomavirus activates canonical Wnt/β-catenin signaling in vivo
A virus protein can activate a pathway that may lead to abnormal hair follicle development.
research 0885 The androgen-THY1 axis mediates sexual dimorphism in dermal adipogenesis and fibrosis
Androgens reduce THY1 in skin cells, leading to less fat, more fibrosis, and worse healing in males.
research A Consensus Single-cell Atlas Of Hidradenitis Suppurativa Tunnels Defines A Fibro-inflammatory Niche With Druggable Microenvironmental Endotypes
The study constructs a consensus single-cell atlas of hidradenitis suppurativa (HS) tunnels by integrating 46 lesional HS single-cell RNA-seq samples from 8 studies. It identifies distinct fibro-inflammatory microenvironmental endotypes within HS tunnels, each associated with specific, potentially druggable signaling pathways. The atlas reveals four main endotypes: one with neutrophil- and macrophage-rich inflammation, another with a Th17/JAK-STAT lymphoid profile, a third with fibroblast expansion and collagen remodeling, and a fourth with hyperproliferative tunnel epithelium. These findings suggest that HS tunnels are not uniform but consist of reproducible microenvironments, which may explain varied responses to treatments. The study highlights that TNF blockade may not be effective for all lesions and suggests that understanding these endotypes can guide more targeted therapeutic and surgical strategies.
research A Consensus Single-cell Atlas Of Hidradenitis Suppurativa Tunnels Defines A Fibro-inflammatory Niche With Druggable Microenvironmental Endotypes
The study constructs a consensus single-cell atlas of hidradenitis suppurativa (HS) tunnels by integrating 46 lesional HS single-cell RNA-seq samples from 8 studies. It identifies distinct fibro-inflammatory microenvironmental endotypes within HS tunnels, each associated with specific, potentially druggable signaling pathways. The atlas reveals four main endotypes: one with neutrophil- and macrophage-rich inflammation, another with a Th17/JAK-STAT lymphoid profile, a third with fibroblast expansion and collagen remodeling, and a fourth with hyperproliferative tunnel epithelium. These findings suggest that HS tunnels are not uniform but consist of reproducible microenvironments, which may explain varied responses to treatments. The study highlights that TNF blockade may not be effective for all lesions and suggests that understanding these endotypes can guide more targeted therapeutic and surgical strategies.
research A Consensus Single-cell Atlas Of Hidradenitis Suppurativa Tunnels Defines A Fibro-inflammatory Niche With Druggable Microenvironmental Endotypes
The study constructs a consensus single-cell atlas of hidradenitis suppurativa (HS) tunnels by integrating 46 lesional HS single-cell RNA-seq samples from 8 studies. It identifies distinct fibro-inflammatory microenvironmental endotypes within HS tunnels, each associated with specific, potentially druggable signaling pathways. The atlas reveals four main endotypes: one with neutrophil- and macrophage-rich inflammation, another with a Th17/JAK-STAT lymphoid profile, a third with fibroblast expansion and collagen remodeling, and a fourth with hyperproliferative tunnel epithelium. These findings suggest that HS tunnels are not uniform but consist of reproducible microenvironments, which may explain varied responses to treatments. The study highlights that TNF blockade may not be effective for all lesions and suggests that understanding these endotypes can guide more targeted therapeutic and surgical strategies.
research A Consensus Single-cell Atlas Of Hidradenitis Suppurativa Tunnels Defines A Fibro-inflammatory Niche With Druggable Microenvironmental Endotypes
The study constructs a consensus single-cell atlas of hidradenitis suppurativa (HS) tunnels by integrating 46 lesional HS single-cell RNA-seq samples from 8 studies. It identifies distinct fibro-inflammatory microenvironmental endotypes within HS tunnels, each associated with specific, potentially druggable signaling pathways. The atlas reveals four main endotypes: one with neutrophil- and macrophage-rich inflammation, another with a Th17/JAK-STAT lymphoid profile, a third with fibroblast expansion and collagen remodeling, and a fourth with hyperproliferative tunnel epithelium. These findings suggest that HS tunnels are not uniform but consist of reproducible microenvironments, which may explain varied responses to treatments. The study highlights that TNF blockade may not be effective for all lesions and suggests that understanding these endotypes can guide more targeted therapeutic and surgical strategies.
research SUN-005 Hirsutism Due to Bilateral Leydig Cell Tumors
A woman's severe hirsutism was caused by Leydig cell tumors in her ovaries, which improved after surgery.
research Sebaceous Trichofolliculoma -A Case Report-
An 18-year-old boy had a harmless skin nodule near his nose with hair and oil glands inside.
research Sub-chronic testosterone treatment increases the levels of epithelial sodium channel (ENaC)-α,βandγin the kidney of orchidectomized adult male Sprague–Dawley rats
Testosterone increases certain kidney protein levels, potentially raising blood pressure.
research 1250 Development of an ex vivo human skin explant model to examine candidate gene functions in the hair follicle and epidermis
The model can effectively test gene functions and drug responses in human skin.
research Hair growth in vitro from histocultured skin
The new system can grow hair in the lab and test hair growth treatments.
research Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration
Bead-jet printing of stem cells improves muscle and hair regeneration.
research 837 Characterization of cutaneous hormone production through analysis of skin secretions
Skin produces different hormones depending on body part and sex, and a new method can measure them.
research Regulation of Hair Follicle Development: An In Vitro Model for Hair Follicle Invasion of Dermis and Associated Connective Tissue Remodeling.
research Identification of Bulge Stem Cells in Mouse and Human Hair Follicles
Scientists found markers called CD34 and CD200 that help identify stem cells in mouse and human hair follicles.
research Establishment and characterization of five immortalized human scalp dermal papilla cell lines
Researchers created five new human scalp cell lines that could be useful for hair growth and loss research.
research 1415 Induction of human hair growth using vascularized 3D hair follicle constructs
Researchers created a 3D-printed skin model that grew human hair when grafted onto mice by improving blood supply to the grafts.
research Disorders linked to insufficient androgen action in male children
Male children's genital development issues can be caused by genetic mutations or environmental factors affecting hormone action.
research ラット精巣におけるビタミンD 代謝関連遺伝子の発現解析
The testes significantly contribute to vitamin D metabolism and may affect male reproductive health and conditions like hair loss.
research Testosterone Down-regulates Expression of αVβ3-integrin, E-cadherin and Mucin-1 during Uterine Receptivity Period in Rats
Testosterone reduces key molecules needed for early pregnancy in rats.
research Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-α Reductase in Human and Fish Cell Lines
A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.