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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

A rare gene variant causes sexual development issues in siblings, needing personalized treatment.

Hormone treatment for transsexual individuals is effective but carries risks like thromboembolic events and mood changes, with most side effects being minor and reversible.

Estrogen-progestin contraception lowers ovarian, endometrial, and colon cancer risk but may raise breast and cervical cancer risk, helps with menstrual and acne issues, and new methods are as effective as pills. Metformin helps overweight women with PCOS and insulin resistance, and dopamine agonists treat prolactinomas.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

Anabolic steroids and SARMs can cause serious liver damage.

The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

The document concludes that health care providers should offer culturally competent care and more research is needed to improve health outcomes for transgender individuals.

Hair can indicate early signs of metabolic disorders, with issues like protein deficiency stopping hair growth.

Clinicians should use social and prescription data to track trends in performance-enhancing drug use.

Microplastics in the Lebanese Mediterranean carry harmful pollutants, posing environmental and health risks.

Counterfeit drugs for bodybuilders often contain incorrect or contaminated ingredients and look like real products.

Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.

The document concludes that gender-affirming treatments are essential for transgender individuals and outlines safe hormone therapy practices.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Careful medical care is needed for those over 50 on hormone therapy during COVID-19.

Long-term anabolic steroid use can lead to heart and metabolic health issues.

Cannabis users may need higher anesthetic doses during hair restoration surgery.

Androgen self-administration might be controlled by membrane receptors, not nuclear ones.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

Anabolic-androgenic steroid abuse can cause heart damage and sudden death.

The guideline emphasizes a multidisciplinary approach and informed consent for gender-affirming hormone treatment, with regular follow-ups and individualized care.

Transgender patients in critical care need better-trained medical staff and specific guidelines.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Testosterone therapy increases bone density in older men with low testosterone levels.

Spironolactone treatment increases the amount of testosterone available in the body.