13 citations
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January 2017 in “Chemical & Pharmaceutical Bulletin” Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.
13 citations
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November 2014 in “Toxicology Letters” Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.
13 citations
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April 1994 in “Journal of Investigative Dermatology” Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
12 citations
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July 2020 in “International Journal of Pharmaceutics” Iron oxide nanoparticles improve skin penetration and drug release for hair loss treatment.
12 citations
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June 2016 in “Reviews in Endocrine and Metabolic Disorders” Some skin diseases and their treatments can negatively affect male fertility.
12 citations
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June 2001 in “Bioorganic & Medicinal Chemistry” Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.
12 citations
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November 1993 in “International Journal of Dermatology” The document explains that hirsutism, often caused by hormonal issues, can be managed with treatment to improve both physical appearance and mental health.
11 citations
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September 2020 in “Steroids” A new method accurately measures steroid hormones in a few hair strands and could help study chronic stress and hair loss.
11 citations
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May 2010 in “Journal of Medicinal Chemistry” A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.
11 citations
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March 2009 in “Bioorganic & Medicinal Chemistry Letters” Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.
11 citations
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February 1980 in “BMJ. British medical journal” Hirsutism is common body hair growth due to genetics and hormones, and while not a disease, it can be distressing; virilisation includes hirsutism with other male traits and needs medical attention.
10 citations
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December 2020 in “Dermatologic Therapy” Minoxidil and spironolactone combo effectively treats androgenetic alopecia, improving hair density and diameter.
10 citations
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January 2019 in “in Vivo” Finasteride boosts stem cell signals for hair growth.
10 citations
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December 2014 in “Journal of Pharmaceutical and Biomedical Analysis” Finasteride's polymorphic form affects capsule quality and drug effect, requiring strict control.
10 citations
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June 2014 in “Journal of Pharmacy and Pharmacology” Germacrone in Curcuma aeruginosa extract degrades at high temperatures but is stable in certain solutions and unaffected by pH levels.
10 citations
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June 2010 in “Expert Opinion on Drug Metabolism & Toxicology” Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.
10 citations
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May 2010 in “Analytica Chimica Acta” New tests detect finasteride and dutasteride in urine quickly and easily.
10 citations
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March 1999 in “Comparative Haematology International” Androgens increase EPO production, finasteride doesn't significantly impact it.
9 citations
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February 2018 in “Journal of Pharmaceutical and Biomedical Analysis” Quick, selective detection of tadalafil and finasteride in human plasma developed.
9 citations
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August 2013 in “Archives of Dermatological Research” A gene called BMAL1 plays a role in controlling hair growth.
8 citations
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June 2020 in “The Journal of Clinical Endocrinology and Metabolism” Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.
8 citations
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June 2019 in “Scientific Reports” Increased PPARGC1α relates to hair thinning in common baldness.
8 citations
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January 2016 in “Evidence-based Complementary and Alternative Medicine” Rumex japonicus extract may promote hair growth more effectively than Minoxidil.
8 citations
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May 1998 in “Journal of Oral and Maxillofacial Surgery” Acne is caused by increased sebum, abnormal skin shedding, bacteria, and inflammation, not dirt; treatments vary from creams to antibiotics or isotretinoin, with severe cases needing a dermatologist's care.
8 citations
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January 1987 in “Gynecological Endocrinology” Flutamide, an antiandrogen, has minimal impact on female rat endocrine systems and does not significantly change their reproductive cycles.
7 citations
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September 2020 in “Journal of Cosmetic Dermatology” Smoking increases early hair loss risk in men; quitting may help prevent it.
7 citations
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January 2020 in “Postepy Dermatologii I Alergologii” Oxidative stress plays a role in female pattern baldness, causing an imbalance between harmful and protective elements in the body.
7 citations
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October 2019 in “Evidence-based Complementary and Alternative Medicine” Chinese medicine may help hair growth and reduce hair loss in androgenetic alopecia.
7 citations
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August 2019 in “Bioorganic & medicinal chemistry” Analog 23 is a promising compound for prostate cancer treatment.
7 citations
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July 2018 in “Biological & Pharmaceutical Bulletin” Phyllanthus urinaria extract may help treat hair loss by blocking a hair-related enzyme.