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Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Torilin from Torilis japonica can inhibit testosterone 5α-reductase but is less effective than finasteride.

Taking oral testosterone with or without dutasteride increases testosterone levels and could be an effective treatment for low testosterone.

Finasteride doesn't affect oral testosterone undecanoate, and high DHT levels may cause acne, prostate issues, and hair loss.

High doses of cyclosporine A increase testosterone conversion, possibly boosting hair growth.

Women have a higher DHT/testosterone ratio than men, possibly due to gut bacteria activity.

Diphlorethohydroxycarmalol may help treat hair loss better than current medications.

Pueraria mirifica extract may help treat benign prostatic hyperplasia.

Green coffee bean extract didn't grow hair but reduced a hair loss-related enzyme in rats.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Inhibiting testosterone 5alpha-reductase may help treat benign prostatic hyperplasia.

Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.

The research helps understand how finasteride works and aids drug development.

Licorice extract helps hair growth and may treat hair loss.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

SRD5A2 gene variations affect PTSD symptoms differently in males and females.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.

24-Hydroxycholesterol reduces DHT formation in brain cancer cells, linking cholesterol and hormone metabolism.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.