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Nicastrin deficiency may cause skin cell damage and pigmentation disorders in humans, similar to effects seen in fish.

Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.

A boy's growth and immune problems were caused by a new mutation in the STAT5B gene.

A teenage girl had both a rare ovarian tumor and a severe form of polycystic ovarian syndrome.

High selenium exposure can harm thyroid function, immune system, liver, skin, and may increase neurotoxicity and cancer risk.

Prepubertal girls with hypertrichosis have more sensitive androgen receptors, leading to increased body hair growth.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

DHT may increase the risk of heart disease and death in elderly men.

Testosterone raises blood pressure and changes kidney protein levels.

Thioglycolic acid in hair products may pose reproductive and cancer risks for hairdressers.

Diphenyl cresyl phosphate has low toxicity but can harm the liver, kidneys, adrenal glands, and testicles at high doses.

GABAergic steroid precursors reduce ethanol withdrawal symptoms in certain mice.

Gender-affirming hormone treatments need better patient-focused outcome measurements and standardized data collection.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Selenosis in calves causes health issues and changes in blood parameters.

Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.

A woman's male-like physical changes were caused by two rare ovarian conditions.

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

Eosinophilia-myalgia syndrome, linked to contaminated L-tryptophan supplements, caused severe symptoms and some deaths, with long-term effects in survivors.

PPX causes much less hair loss than traditional taxanes.

Leydig cell tumors can cause hormone issues in postmenopausal women even if imaging looks normal.

Testosterone affects vascular cells directly without converting to estradiol.

Dihydrotestosterone increases certain inflammatory signals in skin cells, potentially contributing to acne.

Testosterone is important for male development and health, and careful replacement can treat low levels.

Ovarian Leydig cell tumors are hard to diagnose with just advanced imaging; expert ultrasound and clinical evaluation are essential.

Bilateral ovarian hyperthecosis is a rare but treatable cause of increased facial hair in postmenopausal women.

Low-dose oral contraceptives reduced hair growth and testosterone levels in women with polycystic ovary syndrome.

Glyphaea brevis and Monodora myristica can protect against finasteride's harmful effects on blood and oxidative stress in male rats.