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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

Sheep hair follicle transglutaminases are calcium-dependent.

Cathepsin L deficiency causes hair and skin issues in mice.

KIT's role in skin cells is not entirely independent, as other cells can influence its function.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

LGD1069 effectively prevents breast tumors in mice without toxicity.

Immortalized rat dermal papilla cells can still induce hair growth.

Mutations in the WNT10A gene can cause skin, hair, teeth, and other disorders, and may also affect other areas like kidney and cancer, with potential for targeted treatments.

Trichohyalin in sheep hair follicles may help with structure and calcium binding.

Variation in the TCHH gene affects wool curliness in sheep.

Trichohyalin is modified by enzymes to form strong structures in hair cells.

CCC1 is essential for pH balance and normal cell function in plants.

Mouse Scube3 affects teeth, tongue, vibrissae, and eye development, but not facial structure or limb growth.

Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.

A20 protein is crucial for normal skin and hair development.

Deleting Twist1 in skin cells reduces UVB-induced skin cancer risk.

The K5 promoter controls gene expression in skin cells, with specific DNA segments crucial for targeting and regulation.

Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.

FoxN1 gene is crucial for proper thymus structure and normal skin appearance.

Keratin 17 is crucial for cell growth in wound healing by aiding protein synthesis.

Delta1 is crucial for controlling skin cell growth and preventing tumors in mice.

A new MBTPS2 gene variant disrupts fat metabolism and collagen production, causing Osteogenesis imperfecta.

Adding a second method to PROTACs could improve cancer treatment.

HoxC genes are crucial for normal hair and nail development.

HOXC13 is crucial for regulating hair keratin genes in hair follicles.

Erythropoietin overexpression disrupts hair growth and fat formation in mice.

The gene Msx2 is crucial for hair follicle regeneration during wound healing.

Slug (Snai2) helps regulate hair growth timing in mice.