Search

everythinglearnresearchcommunity

for

Search:↓

G-protein-coupled receptors (GPCRs) are crucial in the wound healing process, influencing immune cell recruitment and signaling pathways like Hedgehog-GLI, Hippo-YAP1, and Wnt/β-catenin, which are involved in epidermal cell proliferation and differentiation. By modifying GPCR activity with agonists or antagonists, it is possible to impact immune cell infiltration, inflammatory mediator production, and the rate of wound healing. This review discusses the fundamental mechanisms of GPCR signaling in wound healing and recent discoveries about their roles and functions.

This study explored the role of the PGI2 pathway in diabetic foot ulcers (DFUs) using diabetic mouse models, a three-dimensional cellular model, and clinical studies. The research aimed to understand the alterations in the PGI2 pathway, which is crucial for vascular homeostasis and tissue repair. The study employed three techniques: in vivo skin microvascular reactivity assays, direct activation of PGI2 receptors, and analysis of gene and protein expression. The findings indicated changes in the PGI2 pathway in diabetic mice, particularly in gene and protein expression, but did not show dysfunction in the PGI2-dependent vasomotor effect. The study suggested that targeting the PGI2 pathway could be a potential therapeutic approach for DFUs.