Search

for
Search:

Did you mean Th1 cytokines?

GlossaryTh1 cytokines

signaling proteins produced by Type 1 helper T cells

Th1 cytokines are signaling proteins produced by a type of immune cell called Type 1 helper T cells (Th1 cells). These cytokines, such as interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), play a crucial role in activating and directing other immune cells to fight off intracellular pathogens like viruses and certain bacteria. They are also involved in inflammatory responses, which can be relevant in conditions like autoimmune diseases and alopecia areata.

Related Terms

Sort by

Research

30 / 1000+ results

research Influence of Gushen Shengfa Pills Combined Wuling Capsules on Th1/Th2 Cytokines in Patients with Alopecia Areata Disease

January 2015

Gushen Shengfa pills and Wuling capsules are more effective for hair growth and sleep quality than the control treatment.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

research Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

An Integrated Model of Alopecia Areata Biomarkers Highlights Both Th1/Th2 Upregulation, with Stronger Correlations Between Th2 Activation and Disease Severity

research 1315 An Integrated model of alopecia areata biomarkers highlights both Th1/Th2 upregulation, with stronger correlations between Th2 activation and disease severity

April 2018 in “Journal of Investigative Dermatology”

Both Th1 and Th2 immune responses are increased in alopecia areata, with Th2 response more strongly linked to how severe the disease is.

research An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation

58 citations , July 2018 in “Journal of Allergy and Clinical Immunology”

Alopecia areata severity is linked to increased TH1 and TH2 activity.

research The effect of 5-α reductase inhibitor on Th1, Th2, and Th17 cell-related inflammatory response in BPH

1 citations , April 2023 in “World Journal of Urology”

Finasteride reduces some inflammation in BPH but not all.

Healthy Individuals Genetically At-Risk for the Development of Pemphigus Vulgaris or Alopecia Areata Share Disease-Like Cytokine Dysregulation

research Healthy individuals genetically at-risk for the development of Pemphigus vulgaris or Alopecia areata share disease-like cytokine dysregulation

1 citations , January 2025 in “Frontiers in Immunology”

Genetically at-risk healthy people show similar immune issues as those with Pemphigus vulgaris or Alopecia areata.

research Cytokine profiling of alopecia areata phenotypic subsets

March 2005 in “Journal of the American Academy of Dermatology”

Higher levels of IL-1a and IL-1RA were found in severe alopecia areata cases.

research Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases

25 citations , December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Targeted cytokine treatments may help with alopecia areata, but more research is needed.

research Scalp biomarkers during dupilumab treatment support Th2 pathway pathogenicity in alopecia areata

15 citations , October 2022 in “Allergy”

Dupilumab treatment reduces Th2-related markers and helps hair growth in alopecia areata, showing Th2's role in the condition.

research Pinkie, the First Viable Germline Hypomorph Allele of Retinoid X Receptor Alpha, Reveals an Important Role for RXRa in Th2 Development.

2 citations , November 2004 in “Blood”

RXRa is crucial for Th2 immune cell development and may link nutrition to immune health.

Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

research Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

June 2022 in “Frontiers in Immunology”

Tofacitinib regrew hair in a man with total hair loss but raised cytokine levels, needing more research on possible side effects.

research Alopecia Areata: A Complex Cytokine Driven Disease

3 citations , October 2020 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Alopecia areata is a hair loss disease caused by complex immune reactions, and new targeted treatments show promise.

research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model

69 citations , February 2008 in “The American journal of pathology”

Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.

research Regulatory T cells are required for normal and activin‐promoted wound repair in mice

29 citations , February 2018 in “European Journal of Immunology”

Regulatory T cells are essential for normal and improved wound healing in mice.

research Pathogenesis of paradoxical alopecia areata during dupilumab therapy: What is known and unknown

1 citations , January 2025 in “International Journal of Dermatology”

Dupilumab can both improve and worsen alopecia areata, with higher IgE levels linked to better outcomes.

research From mechanisms to therapies: current advances breakthroughs in alopecia areata immunopathology

3 citations , September 2025 in “Frontiers in Immunology”

JAK inhibitors are effective for treating moderate-to-severe alopecia areata.

research 1313 Fzd2 controls multiple aspects of epidermal development through distinct signaling mechanisms

1 citations , April 2018 in “Journal of Investigative Dermatology”

Fzd2 is important for skin and hair development through various signaling ways.

research A Review on Nanoparticle Based Herbal Remedies for the Management of Alopecia

January 2020 in “Der Pharmacia Lettre”

Nanoparticle-based herbal remedies could be promising for treating hair loss with fewer side effects and lower cost, but more research is needed.

research Optimisation of a Murine Infection Model With Trichophyton mentagrophytes for Studying the Pathogenesis of Dermatophytosis

December 2025 in “Mycoses”

The study developed a successful mouse model to study skin infections, highlighting the importance of choosing the right fungal strains.

research Overlapping features of atopic dermatitis and alopecia areata: from pathogenesis to treatment

September 2025 in “Frontiers in Immunology”

Atopic dermatitis and alopecia areata share immune and genetic factors, and targeted therapies may help both.

research A novel therapeutic paradigm for patients with extensive alopecia areata

30 citations , May 2016 in “Expert Opinion on Biological Therapy”

New treatments targeting immune pathways show promise for severe hair loss but need more research for safety and effectiveness.

research Biomarkers of alopecia areata disease activity and response to corticosteroid treatment

65 citations , December 2015 in “Experimental dermatology”

Corticosteroid treatment reduces inflammation and alters hair keratins in alopecia areata.

research Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata

12 citations , March 2016 in “BBA clinical”

Increased Toll-like receptors in blood cells may contribute to alopecia areata and could be a target for new treatments.

research Markers of inflammation, metabolic disorders, and principles of treatment for alopecia areata in children

January 2025 in “Voprosy praktičeskoj pediatrii”

Janus kinase inhibitors show promise for treating alopecia areata in children.

research A Potential Role for IL-4 and IL-13 in an Alopecia Areata–Like Phenotype: A Clinical Perspective

4 citations , October 2020 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

IL-4 and IL-13 might play a role in a type of hair loss similar to alopecia areata.

research 1318 Both lesional and non-lesional skin from acne patients shows robust IL-17-skewing and upregulation of antimicrobial peptides

April 2018 in “Journal of Investigative Dermatology”

Acne patients' skin, both with and without lesions, shows a strong immune response and higher antimicrobial activity.

research Phenotypic Analysis of T-Cells in Extensive Alopecia Areata Scalp Suggests Partial Tolerance

21 citations , December 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

T-cells in alopecia areata scalp show abnormal regulation, leading to less inflammation.

Alopecia Universalis Following Two Sequential Traffic Accidents: Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells

research Alopecia Universalis Following Two Sequential Traffic Accidents : Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells

4 citations , January 2011 in “Journal of UOEH”

Autoimmune hair loss may be linked to increased Th1 and Th17 cells and decreased Th2 cells.

research Th1/Th2 PB balance and CD200 expression of patients with active severe alopecia areata

12 citations , April 2017 in “Experimental and Therapeutic Medicine”

Patients with severe active alopecia areata have lower CD200 expression and an imbalance in their immune system.