130 citations
,
November 2017 in “Frontiers in Immunology” The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.
75 citations
,
January 2009 in “International journal of trichology” Hair grays due to oxidative stress and fewer functioning melanocytes.
40 citations
,
March 2022 in “Small” Hydrogel with M2-derived exosomes improves wound healing by slowly releasing exosomes that help reduce inflammation and promote tissue repair.
39 citations
,
January 2019 in “Cells” Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.
27 citations
,
April 2017 in “Journal of Investigative Dermatology” After skin is damaged, noncoding dsRNA helps prostaglandins and Wnts work together to repair tissue and promote hair growth.
15 citations
,
March 2014 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.
12 citations
,
January 1998 in “Endocrine journal” Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.
6 citations
,
September 2024 in “Journal of Clinical Medicine” Thyroid and skin autoimmune diseases share genetic and immune links, affecting both tissues.
6 citations
,
January 2010 in “Springer eBooks” SA linked to mitochondrial issues and oxidative stress, while AGA involves disrupted hair growth genes.
5 citations
,
October 2014 in “Journal of cosmetic and laser therapy” Combining physical dermabrasion with chemical peeling is more effective for skin treatment than chemical peeling alone.
1 citations
,
November 2017 The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.
Blocking autophagy worsens lipid buildup and dysfunction in brain cells after injury.
January 2024 in “Oxford medical case reports” Standard treatment for congenital erythropoietic porphyria was ineffective over five years.
August 2023 in “Bioengineering” Bioprinting could greatly improve health outcomes but faces challenges like material choice and ensuring long-term survival of printed tissues.
Enhanced stem cells from the placenta can reduce fat cell formation in eye disease.
September 2017 in “Journal of Investigative Dermatology” Injections of special skin cells showed potential in treating hair loss, with some participants experiencing increased hair density.
7 citations
,
December 2021 in “European Respiratory Review” The document concludes that diagnosing and treating Interstitial Pneumonia with Autoimmune Features (IPAF) is challenging, needs a multidisciplinary approach, and further research for better diagnostic criteria and treatments. It also emphasizes regular checks for Connective Tissue Disease symptoms in all patients with Interstitial Lung Disease.
46 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Disrupting Acvr1b in mice causes severe hair loss and thicker skin.
1039 citations
,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
403 citations
,
November 2005 in “Journal of Endocrinology” Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.
169 citations
,
June 2010 in “Molecular & cellular proteomics” Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.
148 citations
,
April 2009 in “Molecular Pharmaceutics” Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.
82 citations
,
October 2019 in “Frontiers in Immunology” Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.
73 citations
,
April 2013 in “Stem cells” LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.
68 citations
,
September 2018 in “Trends in Cell Biology” Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.
48 citations
,
July 2008 in “Acta Biochimica et Biophysica Sinica” Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.
47 citations
,
June 2012 in “Genes & Development” A mother's western diet can make her milk toxic, causing inflammation and hair loss in babies.
42 citations
,
December 2016 in “Cell Death & Differentiation” Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.
39 citations
,
August 2017 in “Colloids and Surfaces B: Biointerfaces” 50-nm nanoparticles are better at penetrating skin and targeting hair follicles for drug delivery than 100-nm ones.
38 citations
,
July 2019 in “Nature Communications” Par3 protein is essential for skin cell balance and stability.