109 citations
,
June 2011 in “Molecular and Cellular Endocrinology” Vitamin D receptor mutations can cause alopecia by affecting hair growth genes.
86 citations
,
August 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” Vitamin D and calcium are essential for effective wound healing and hair growth.
4 citations
,
May 2006 in “médecine/sciences” The hairless gene is crucial for hair health, and its mutations cause hair loss.
96 citations
,
August 1995 in “Bone” Vitamin D3 is important for bone health and may help treat various diseases beyond bone-related conditions.
34 citations
,
August 2012 in “Calcified Tissue International”
9 citations
,
October 2017 in “Archivos Argentinos de Pediatria” Alopecia areata needs new treatments targeting autoimmune processes due to its emotional impact and variable treatment responses.
9 citations
,
January 2015 in “Current problems in dermatology” Scientists have found specific genes linked to different hair loss conditions, which could lead to new treatments.
133 citations
,
January 2009 in “Nature” Lgr5 and the vitamin D receptor are key in controlling skin inflammation and tumor risk in mice.
76 citations
,
January 2010 in “Journal of bone and mineral metabolism” 35 citations
,
April 2008 in “Journal of Biological Chemistry” Hirosaki hairless rats lack hair due to missing DNA with key keratin genes.
August 2020 in “Pakistan Journal of Zoology” A new mutation in the Hairless gene causes hair loss in two Pakistani families.
479 citations
,
June 2014 in “Science” Epithelial stem cells can adapt and help in tissue repair and regeneration.
421 citations
,
January 2015 in “Chemical Society Reviews” Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.
418 citations
,
September 2012 in “Nature” African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.
295 citations
,
June 2009 in “Science” Stromal stem cells may help heal wounds by becoming structural cells or affecting the immune system, but more research is needed to understand how.
294 citations
,
January 2016 in “Stem Cells International” Adipose-derived stem cells are promising for tissue and organ repair due to their easy access and versatility.
252 citations
,
April 2009 in “Seminars in Cell & Developmental Biology” The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.
228 citations
,
September 2012 in “Trends in Neurosciences” Nerves are crucial for the regeneration of various body parts in many animals.
220 citations
,
March 2020 in “Advanced functional materials” Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.
208 citations
,
January 2013 in “Lab on a Chip” The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.
201 citations
,
April 2017 in “Regeneration” Macrophages and fibroblasts help repair organs after injury, affecting whether they regenerate or scar.
200 citations
,
March 2023 in “Nature Reviews Molecular Cell Biology” Quiescent adult stem cells are crucial for tissue repair and maintenance.
192 citations
,
January 2018 in “Burns & Trauma” Current skin substitutes help heal severe burns but don't fully replicate natural skin features.
188 citations
,
March 2018 in “Frontiers in Immunology” Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.
184 citations
,
December 2018 in “Nature Communications” Researchers created human hair follicles using a new method that could help treat hair loss.
177 citations
,
April 2008 in “Biomedical Materials” Human hair proteins can be used to create scaffolds that support cell growth for tissue engineering.
165 citations
,
January 2008 in “Journal of biomaterials science. Polymer ed.” The peptide GHK-Cu helps heal and remodel tissue, improves skin and hair health, and has potential for treating age-related inflammatory diseases.
140 citations
,
March 2013 in “The journal of immunology/The Journal of immunology” Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.
133 citations
,
July 2020 in “Cells” Creating fully functional artificial skin for chronic wounds is still very challenging.
119 citations
,
March 2020 in “Frontiers in Bioengineering and Biotechnology” Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.