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GlossaryTopical Vitamin D

applied skin treatment to regulate cell growth and inflammation

Topical Vitamin D refers to a form of Vitamin D that is applied directly to the skin, often in the form of a cream or ointment. It is commonly used to treat skin conditions such as psoriasis and eczema by helping to regulate skin cell growth and reduce inflammation. In the context of hair and alopecia, topical Vitamin D may be used to promote hair growth and improve scalp health, as Vitamin D plays a role in the hair follicle cycle.

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Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans

research 'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans

47 citations , July 2005 in “British Journal of Dermatology”

Topical vitamin D3 does not prevent hair loss from chemotherapy.

research Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

26 citations , March 2014 in “Journal of cutaneous medicine and surgery”

Topical vitamin D is useful for some skin conditions but not effective for others, and more research is needed.

research The Role of Topical Vitamin D in Vitiligo: A Narrative Literature Review

2 citations , September 2022 in “Bioscientia medicina”

Topical vitamin D is effective in treating vitiligo with few side effects.

research Topical application of vitamin D cream in particiants with inflammatory acne due to vitamin D deficiency

April 2024 in “International Journal Of Medical Science And Clinical Invention”

Vitamin D cream significantly reduces acne in people with vitamin D deficiency.

research Topical Calcipotriol versus oral vitamin D in the treatment of alopecia areata

3 citations , March 2019 in “Fayoum University Medical Journal/Fayoum University Medical Journal ”

Rubbing calcipotriol on the skin works better than taking vitamin D pills for treating mild to moderate alopecia areata.

research Comparison of Treatment with Oral Vitamin D Alone, Topical Minoxidil or Combination of Both in Patients of Female Pattern Hairloss

January 2025

Combining oral vitamin D with topical minoxidil is most effective for improving female pattern hair loss.

research Topical cetirizine and oral vitamin D: a valid treatment for hypotrichosis caused by ectodermal dysplasia

4 citations , August 2016 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Using cetirizine on the skin and taking vitamin D can help increase hair growth in children with hair loss from ectodermal dysplasia.

research Topical minoxidil and tretinoin combined with an oral vitamin D analog as a treatment for woolly hair

3 citations , February 2016 in “Dermatologic Therapy”

Using minoxidil and tretinoin on the skin, along with oral vitamin D, improved hair thickness and density in two girls with woolly hair.

Treatment with Oral Vitamin D Alone, Topical Minoxidil, or Combination of Both in Patients with Female Pattern Hair Loss: A Comparative Clinical and Dermoscopic Study

research Treatment with oral vitamin D alone, topical minoxidil, or combination of both in patients with female pattern hair loss: A comparative clinical and dermoscopic study

1 citations , January 2022 in “Journal of Cosmetic Dermatology”

Taking oral vitamin D and applying topical minoxidil together can better treat female pattern hair loss than using either treatment alone.

research Topical sunscreens and vitamin D

July 2012 in “British Journal of Dermatology”

Hair loss treatments show limited improvement, sunscreen thickness affects vitamin D production, and the effectiveness of IVIg for toxic epidermal necrolysis is uncertain.

A Topical Scalp Serum Containing Adenosine, Magnesium Sulfate, Vitamin C Glucoside, and Pre- and Probiotic Fractions Reduces Discomfort and Associated Symptoms of Sensitive Scalp

research A Topical Scalp Serum Containing Adenosine, MgSO4, Vitamin CG, and Pre- and Probiotic Fractions Reduces Discomfort and Associated Symptoms of Sensitive Scalp

November 2023 in “Dermatologic therapy”

The scalp serum reduced scalp discomfort and symptoms without affecting skin moisture loss.

Effect of Topical Applications of Oils Extracted from Medicinal Plants and Coconut Oil Mixed with Egg Yolk and Vitamin E on Growth of Rabbit Hair in District Karak, Khyber Pakhtunkhwa, Pakistan

research Effect of topical applications of oils extracted from medicinal plants and coconut oil mixed with egg yolk and vitamin e on growth of rabbit hair of District Karak, Khyber Pakhtunkhwa, Pakistan

July 2020 in “International journal of biology sciences”

Coconut oil mixed with egg yolk and vitamin E may improve rabbit hair growth more than other plant oils.

research Vitamin D and skin diseases: A review

48 citations , January 2015 in “Indian Journal of Dermatology, Venereology and Leprology”

Vitamin D is important for skin health and can help treat psoriasis, atopic dermatitis, and vitiligo.

research The Role of Vitamin D in Non-Scarring Alopecia

32 citations , December 2017 in “International Journal of Molecular Sciences”

Low vitamin D might be linked to certain types of hair loss, and supplements could help, but more research is needed.

research Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia

20 citations , May 2016 in “Journal of Cosmetic Dermatology”

Low vitamin D receptor levels found in hair loss patients; topical vitamin D treatment suggested.

research Serum vitamin D level and disease severity of alopecia areata: A meta-regression analysis

5 citations , May 2018 in “Journal of the American Academy of Dermatology”

Lower vitamin D levels might be linked to more severe alopecia areata, but more research is needed to understand if vitamin D can help treat it.

research Prevalence of Low Serum Vitamin D Levels in Patients Presenting With Androgenetic Alopecia: A Review

2 citations , December 2021 in “Cureus”

Low vitamin D levels are linked to hair loss, and vitamin D might help treat it.

research Vitamin D and Skin: An Review and Update

April 2024 in “Nepal journal of dermatology, venereology & leprology”

Vitamin D is important for skin health and can help treat and prevent various skin conditions.

Vitamin D in Dermatology and Cosmetology

research Dermatoloji ve Kozmetolojide D Vitamini

June 2022

Vitamin D is crucial for skin health and managing skin diseases.

research Combination of topical anthralin and calcipotriene in alopecia areata: A discussion of the mechanisms of action

May 2020 in “JAAD case reports”

Using anthralin and calcipotriene together might help treat tough cases of alopecia areata, but more research is needed to understand how it works.

$Complete Clinical and Trichoscopic Remission of Refractory Patch Alopecia Areata with a Multi-Modal Microneedling and Vitamin D3 Protocol: A Case Report$

research Complete Clinical and Trichoscopic Remission of Refractory Patch Alopecia Areata with a Multi-Modal Microneedling and Vitamin D3 Protocol: A Case Report

November 2025 in “Bioscientia Medicina Journal of Biomedicine and Translational Research”

A combined treatment with microneedling and vitamin D3 led to complete hair regrowth in a woman with stubborn patch alopecia areata.

research Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.

August 2025 in “PubMed”

Vitamin D3 helps treat mild to moderate alopecia areata, especially when combined with other treatments.

research Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial

February 2023 in “Journal of Cosmetic Dermatology”

Combining microneedling with either vitamin D3 or bimatoprost improves hair regrowth more than microneedling alone.

research Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy.

14 citations , January 2019 in “PubMed”

Vitamin D might be involved in the development of alopecia areata and could help in its treatment.

research Vitamin D3 and chemotherapy-induced alopecia

11 citations , June 1996 in “Nutrition”

Vitamin D3 may prevent hair loss from chemotherapy, but side effects and cancer cell protection are concerns.

Special Focus Issue: Transdermal, Topical, and Follicular Drug Delivery Systems

research Special Focus Issue: Transdermal, Topical and Folicular Drug Delivery Systems

5 citations , March 2016 in “Drug Development and Industrial Pharmacy”

New drug delivery systems improve treatment effectiveness and patient experience.

Response to 'Vitamin D Status in Scarring and Nonscarring Alopecia'

research Reply to “Vitamin D status in scarring and nonscarring alopecia”

May 2022 in “Journal of the American Academy of Dermatology”

The document suggests using a topical Vitamin D treatment for hair loss rather than oral supplements and calls for more research.

Case of Eyebrow Alopecia Areata Treated with Combination of Secretome, 5% Topical Minoxidil, and Topical Corticosteroids

research Kasus eyebrow alopesia areata yang diterapi dengan kombinasi sekretom, minoxidil 5% topikal dan kortikosteroid topikal

October 2024 in “Intisari Sains Medis”

Combining secretome with other treatments quickly improves eyebrow hair growth in alopecia areata.

research Protection against cyclophosphamide‐induced alopecia and inhibition of mammary tumor growth by topical 1,25‐dihydroxyvitamin D3 in mice

1 citations , January 1998 in “International journal of cancer”

Rubbing vitamin D3 on skin can help prevent hair loss from chemotherapy and slow breast tumor growth in mice.

research Faculty Opinions recommendation of Topical minoxidil reported hair discoloration: a cross-sectional study.

August 2023 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Minoxidil users may experience hair discoloration, especially with long-term use and a family history of gray hair.