research Follicle-innervating Aδ-low threshold mechanoreceptors organize through a population-dependent mechanism
Mouse touch-sensitive nerve cells adjust their connections based on competition with other similar cells.
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90-120 / 1000+ results research Three-dimensional microanatomy of mechanoreceptors and their possible mechanism of sensory transduction.
Mechanoreceptors convert physical touch into electrical signals through specialized nerve structures.
research 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification
Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.
research Itraconazole therapy for recalcitrant dermatophyte infections
Itraconazole helps improve tough skin infections but may not prevent them from coming back.
research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn
Delta opioid receptors help regulate touch sensation by reducing neurotransmitter release in the spinal cord.
research Adaptations in the structure and innervation of follicle‐sinus complexes to an aquatic environment as seen in the Florida manatee (Trichechus manatus latirostris)
Manatee whiskers are specially adapted for touch in water.
research Anatomical Mapping and Density of Merkel Cells in Skin and Mucosae of the Dog
Dogs have varying numbers of touch-sensitive Merkel cells in different skin areas, with most in the oral mucosa and facial skin, unrelated to age, sex, breed, or color.
research Decision letter: Hair follicle epidermal stem cells define a niche for tactile sensation
Hair follicle stem cells are crucial for touch sensation and proper nerve structure in mice.
research Tissue‐engineering approaches to enhance nerve regeneration during wound healing
Two methods improved nerve regeneration and touch recovery in skin grafts for burn patients.
research Acne keloidalis nuchae: prevalence, impact, and management challenges
Acne keloidalis nuchae is a tough-to-treat condition that greatly affects quality of life, especially in men of African descent.
research Stem cell therapy as a novel therapeutic intervention for resistant cases of alopecia areata and androgenetic alopecia
Stem cell therapy may help treat tough hair loss cases.
research Known and Unknown Features of Hair Cuticle Structure: A Brief Review
The hair cuticle is made of tough proteins that protect the hair, but more research is needed to fully understand its structure.
research Efficacy and safety of baricitinib in patients with refractory alopecia areata
Baricitinib helped some patients with tough-to-treat hair loss regrow hair, but more research is needed on its safety.
research Colistin adorned topical nanoemulsion gel formulation for enhanced anti-microbial activity
The new gel improves treatment of tough skin infections.
research Closing the loop with citramalic acid-based chiral polyester: A novel strategy as a game-changer for sustainable materials
A new sustainable polyester is tough, recyclable, biodegradable, and aids wound healing, supporting a circular economy.
research Fracture in Hierarchical Biomaterials: Human Hair
Human hair's structure makes it tough and resistant to breaking.
research [Dermatologic therapy unit anti-androgens].
Anti-androgens can help treat tough skin conditions like severe acne and excessive hair growth.
research The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles
Lanceolate complexes in mouse hair follicles are essential for touch and depend on specific cells for maintenance and regeneration.
research KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors
KCNQ potassium channels help control the sensitivity of touch receptors in the skin.
research The development of cutaneous afferent pathways in fetal sheep: a structural and functional study
Fetal sheep develop skin nerve pathways and responses to touch and heat between 75 and 134 days of gestation.
research Author response: Hair follicle epidermal stem cells define a niche for tactile sensation
Skin stem cells in hair follicles are important for touch sensation.
research Characterization of the Human Hair Shaft Cuticle–Specific Keratin-Associated Protein 10 Family
KRTAP10 proteins help form the hair shaft's tough outer layer by interacting with specific hair keratins.
research Combination of topical anthralin and calcipotriene in alopecia areata: A discussion of the mechanisms of action
Using anthralin and calcipotriene together might help treat tough cases of alopecia areata, but more research is needed to understand how it works.
research Role of Robotics in Neuromodulator and Filler Injections of Face
Robotics in facial injections offers precision but is costly and lacks personal touch.
research Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles
BK and Kv4.2 channels help Merkel cells in rat whiskers sense touch.
research Follicular Transplantation, Microneedling, and Adjuvant Narrow-band Ultraviolet-B Irradiation as Cost-Effective Regimens for Palmar-Plantar Vitiligo: A Pilot Study
Combining hair transplantation with microneedling or laser and UV light may help treat tough vitiligo on hands and feet, with microneedling being affordable and easy to learn.
research The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons
Different hair follicles in the skin are innervated by unique combinations of mechanosensory neurons, crucial for touch sensation.
research A subpopulation of itch‐sensing neurons marked by Ret and somatostatin expression
Scientists found a specific group of itch-sensing nerve cells in mice important for feeling itch but not for sensing heat or touch.
research The Function and Structure of the Skin
The skin protects the body, regulates temperature, senses touch, and makes vitamin D.
research Merkel cell carcinoma: updates in tumor biology, emerging therapies, and preclinical models
New therapies and trials are needed for Merkel cell carcinoma, a tough skin cancer.