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930-960 / 1000+ resultsresearch Phase I safety and pharmacokinetic study of SU-014813 in combination with docetaxel in patients with advanced solid tumours
The drug combination was safe and showed promise in treating advanced tumors.
research Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails
Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.
research The use of hair cortisol for the assessment of stress in animals
Hair cortisol is a reliable way to measure long-term stress in animals.
research Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System
EGFR-TKIs can cause significant skin, nail, and organ side effects.
research Studies on the persistence of estradiol benzoate and nortestosterone decanoate in hair of cattle following treatment with growth promoters, determined by ultra-high-performance liquid chromatography–tandem mass spectrometry
Detecting steroid esters in cattle hair is inconsistent and influenced by sampling factors.
research Different localizations of drugs simultaneously administered in a strand of hair by micro‐segmental analysis
Drugs localize differently in hair strands based on their properties.
research Studies on neurosteroids XXIV. Determination of neuroactive androgens, androsterone and 5α‐androstane‐3α,17β‐diol, in rat brain and serum using liquid chromatography–tandem mass spectrometry
The methods accurately measured brain androgens, showing most 5α-androstane-3α,17β-diol comes from outside the brain, while androsterone is both transported and made in the brain.
research Referee report. For: Drug utilization pattern and adverse drug reactions of chemotherapy in pediatric patients at Muhimbili National Hospital, Tanzania [version 1; peer review: 1 approved, 1 approved with reservations]
Most pediatric cancer patients at Muhimbili National Hospital experienced adverse drug reactions during chemotherapy, highlighting the need for careful monitoring.
research Comprehensive Administrative and Engineering Strategies for Radiation Protection and Occupational Health Safety
Implementing safety strategies is crucial to prevent radiation-related health issues.
research Identification of hydroxylated and glucuronidated metabolites of finasteride in human bile and urine
Finasteride is extensively metabolized in the body, affecting its effectiveness and safety.
research Hyaluronidase Modulates Inflammatory Response and Accelerates the Cutaneous Wound Healing
Hyaluronidase speeds up wound healing and reduces inflammation.
research Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review
The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.
research Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development
Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.
research Exploring the Interplay between Arsenic and Cutaneous Physiology, Pathology, and Regeneration
Arsenic exposure from contaminated water severely damages the skin, causing hair loss, pigmentation changes, irritation, and can lead to skin cancer.
research Effect of Particle Size on Physical Properties, Dissolution, In Vitro Antioxidant Activity, and In Vivo Hepatoprotective Properties of Tetrastigma hemsleyanum Diels et Gilg Powders
Smaller particle sizes of Tetrastigma hemsleyanum powders improve their effectiveness and liver health benefits.
research Potential Health Risks Associated with Cosmetics and Personal Care Products: An Overview
Cosmetics can contain harmful chemicals that may cause health issues.
research Analysis of potentially toxic contaminants in milk powder
Milk powder in Romania often has unsafe levels of aluminum and other elements, posing health risks.
research Glucocorticoids and mineralocorticoids in hair: facilitating accurate diagnosis of adrenal-related endocrine disorders
Hair analysis can help diagnose adrenal disorders non-invasively.
research Electron beam tomography quantitation of coronary calcium and assessment for ischemic coronary disease: a complement to stress testing
Electron Beam Tomography (EBT) is a useful additional test to stress testing for detecting heart disease.
research Measurement of tamsulosin in human serum by liquid chromatography–tandem mass spectrometry
A reliable method was created to measure tamsulosin in human blood.
research Determination of traces of silver in human scalp hair slurries by electrothermal atomic absorption spectrometry
research Spermidine/spermine-N1-acetyltransferase: a key metabolic regulator
SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.
research Comparative GC-MS Based In vitro Assays of 5α-Reductase Activity Using Rat Liver S9 Fraction
The S9 fraction with GC-IDMS is effective for measuring 5α-reductase activity.
research Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate
TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.
research Effect of human hair keratin on the function of rat liver,renal,heart and hematology profile
Hair keratin doesn't significantly affect rat organ function but may help detect early rejection through blood changes.
research Bridging the organoid translational gap: integrating standardization and micropatterning for drug screening in clinical and pharmaceutical medicine
Standardizing and engineering organoids can improve their use in medicine and drug testing.
research Small cell lung cancer: Results of a phase II study of 1,2,4 triglycidylurazol
The drug TGU was ineffective against small cell lung cancer and caused significant bone marrow suppression.
research Chronic exposures to the herbicide atrazine and the pharmaceutical finasteride disrupt sex steroid and thyroid hormone signalling and gonadal development in frogs
Atrazine and finasteride disrupt hormone signaling and affect frog development.
research MP09-17 METHYLATION OF SRD5A2 IN THE BLOOD AS A NOVEL BIOMARKER TO PREDICT SENSITIVITY TO 5-ARI TREATMENT
SRD5A2 methylation in blood can predict how well someone will respond to finasteride treatment.