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Did you mean Transepidermal Water Loss?

GlossaryTransepidermal Water Loss

water evaporates from the skin's surface, indicating barrier function

Transepidermal Water Loss (TEWL) refers to the process by which water passes from the inside of the body through the epidermis (the outermost layer of the skin) and evaporates into the environment. It is a key indicator of the skin's barrier function; higher TEWL values suggest a compromised skin barrier, which can lead to dryness, irritation, and conditions like eczema.

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research Effects of dietary camelina, flaxseed, and canola oil supplementation on inflammatory and oxidative markers, transepidermal water loss, and coat quality in healthy adult dogs

7 citations , March 2023 in “Frontiers in Veterinary Science”

Camelina oil can improve dog coat quality like flaxseed and canola oils.

research Epidermis-specific ablation of claudin-1 in adult mice demonstrates the essential role of a tight junction barrier in skin homeostasis

1 citations , September 2016 in “Journal of Dermatological Science”

Claudin-1 is crucial for maintaining skin barrier and preventing inflammation.

Amelioration of Symptoms of Dry and Eczema-Prone Skin by an Oil-in-Water Emulsion Containing a Combination of Zingiber Officinale Root Extract and CBD with Antioxidative and Anti-Inflammatory Activity In Vitro

research 599 Amelioration of symptoms of dry and eczema-prone skin by an oil-in-water emulsion containing a combination of a zingiber officinale root extract and cbd with antioxidative and anti-inflammatory activity in vitro

April 2023 in “Journal of Investigative Dermatology”

An oil-in-water emulsion with CBD and ginger root extract significantly improved symptoms of dry and eczema-prone skin.

research Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation

32 citations , April 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Loss of keratin K2 causes skin problems and inflammation.

research Artificial Intelligence-Based Personalization of Treatment Regimen for Hair Loss: A 6-Month Clinical Trial.

February 2025 in “PubMed”

AI-personalized hair loss treatments improved hair growth and scalp health without side effects.

Skin Manifestations and Biophysical Properties in Patients With Morbid Obesity and Changes After Weight Loss: A Two-Year Prospective Study

research 393 Skin manifestations and biophysical properties in patients with morbid obesity and changes after weight loss: A two-year prospective study

April 2023 in “Journal of Investigative Dermatology”

Weight loss surgery improved several skin conditions in obese patients but often caused hair loss.

research Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell–Conditioned Medium

33 citations , September 2019 in “Dermatologic Surgery”

Using a special stem cell formula on the scalp once a month for six months helped people with hair loss grow more hair.

research Experimental and Clinical Efficacy of Two Hyaluronic Acid-based Compounds of Different Cross-Linkage and Composition in the Rejuvenation of the Skin

20 citations , June 2014 in “Pharmaceutical research”

Using both hyaluronic acid compounds together improves skin hydration and reduces wrinkles better than using one alone.

research Occlusion and hydration of scars: moisturizers versus silicone gels

8 citations , April 2022 in “Burns”

Alhydran and DermaCress moisturizers are more effective and cost-efficient for scar hydration than silicone gel.

research Treatment of periorbital aging with negative pressure fractional microneedle radiofrequency: A self‐controlled clinical trial

4 citations , November 2023 in “Journal of Cosmetic Dermatology”

Negative pressure fractional microneedle radiofrequency effectively and safely reduces periorbital aging signs.

research A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

1 citations , May 2017 in “Asian journal of medical sciences”

The dietary supplement significantly improved skin, nails, and hair in older adults.

research The fatty acids and the skin: a focus on the n-6 family of unsaturated fatty acids

1 citations , January 2012 in “Human health handbooks”

Linoleic acid is important for healthy skin, and while most people get enough from their diet, not having enough can cause skin and hair problems.

research POLEVAN®—A Multifunctional Natural Hair Ingredient, as Determined by In-Vitro and Human Studies

November 2025 in “Cosmetics”

POLEVAN® improves hair shine, moisturizes the scalp, and maintains foam quality in shampoos.

Efficacy of Thermus Thermophilus Fermentation Extract in Promoting Hair Growth and Improving Scalp Health in Androgenic Alopecia: A Clinical and In Vitro Study

research Efficacy of Thermus thermophilus Fermentation Extract in Promoting Hair Growth and Improving Scalp Health in Androgenic Alopecia: A Clinical and In Vitro Study

March 2025 in “Journal of Cosmetic Dermatology”

Thermus thermophilus extract improves hair growth and scalp health in men with hair loss.

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

January 2025 in “International Journal of Molecular Sciences”

Non-liganded Vitamin D Receptor is crucial for healthy skin and hair.

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

November 2024

Vitamin D receptor actions without binding are crucial for healthy skin and hair.

research The fatty acids and the skin: a focus on the n-6 family of unsaturated fatty acids

November 2012

Linoleic acid is essential for healthy skin, and while deficiency is rare in Western societies, it can cause dry, scaly skin and hair loss.

25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

research 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

research Stratum corneum dysfunction in dandruff

93 citations , April 2012 in “International Journal of Cosmetic Science”

Improving skin barrier and using antifungal treatments can help manage dandruff.

research Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 ^-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation

87 citations , March 2007 in “Biological Chemistry”

Deleting the scd1 gene in mice prevents obesity by disrupting skin lipids and improving heat regulation.

research Antioxidant and Cytoprotective Properties of Plant Extract from Dry Flowers as Functional Dyes for Cosmetic Products

48 citations , May 2021 in “Molecules”

Plant extracts from dry flowers can be used as safe, effective dyes in cosmetics, offering skin protection and anti-aging benefits.

research Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production

40 citations , July 2019 in “Journal of Investigative Dermatology”

Lack of a key enzyme causes severe skin issues and death in mice.

An Investigation of In Vivo Wound Healing Activity of Biologically Synthesized Silver Nanoparticles

research Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation

34 citations , August 2019 in “Journal of Allergy and Clinical Immunology”

mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.

research Caffeine improves barrier function in male skin

33 citations , September 2006 in “International Journal of Cosmetic Science”

Caffeine improves male skin's barrier function.

research The acyl-CoA binding protein is required for normal epidermal barrier function in mice

31 citations , July 2012 in “Journal of Lipid Research”

ACBP is crucial for healthy skin in mice.

research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

27 citations , July 2017 in “Scientific Reports”

N-WASP is essential for healthy skin and preventing inflammation.

research Menopause, skin and common dermatoses. Part 2: skin disorders

25 citations , June 2022 in “Clinical and Experimental Dermatology”

Menopause significantly affects skin health and conditions.

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Related Terms

Research

research Effects of dietary camelina, flaxseed, and canola oil supplementation on inflammatory and oxidative markers, transepidermal water loss, and coat quality in healthy adult dogs

research Epidermis-specific ablation of claudin-1 in adult mice demonstrates the essential role of a tight junction barrier in skin homeostasis

research 599 Amelioration of symptoms of dry and eczema-prone skin by an oil-in-water emulsion containing a combination of a zingiber officinale root extract and cbd with antioxidative and anti-inflammatory activity in vitro

research Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation

research Artificial Intelligence-Based Personalization of Treatment Regimen for Hair Loss: A 6-Month Clinical Trial.

research 393 Skin manifestations and biophysical properties in patients with morbid obesity and changes after weight loss: A two-year prospective study

research Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell–Conditioned Medium

research Experimental and Clinical Efficacy of Two Hyaluronic Acid-based Compounds of Different Cross-Linkage and Composition in the Rejuvenation of the Skin

research Occlusion and hydration of scars: moisturizers versus silicone gels

research Treatment of periorbital aging with negative pressure fractional microneedle radiofrequency: A self‐controlled clinical trial

research A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

research The fatty acids and the skin: a focus on the n-6 family of unsaturated fatty acids

research POLEVAN®—A Multifunctional Natural Hair Ingredient, as Determined by In-Vitro and Human Studies

research Efficacy of Thermus thermophilus Fermentation Extract in Promoting Hair Growth and Improving Scalp Health in Androgenic Alopecia: A Clinical and In Vitro Study

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

research The fatty acids and the skin: a focus on the n-6 family of unsaturated fatty acids

research 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

research Stratum corneum dysfunction in dandruff

research Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 ^-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation

research Antioxidant and Cytoprotective Properties of Plant Extract from Dry Flowers as Functional Dyes for Cosmetic Products

research Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production

research An investigation of in vivo wound healing activity of biologically synthesized silver nanoparticles

research Age-Related Changes in Male Skin: Quantitative Evaluation of One Hundred and Fifty Male Subjects

research Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole‐body energy expenditure

research Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation

research Caffeine improves barrier function in male skin

research The acyl-CoA binding protein is required for normal epidermal barrier function in mice

research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

research Menopause, skin and common dermatoses. Part 2: skin disorders