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Glossarytranscriptomics

study of RNA transcripts to understand gene activity and regulation

Transcriptomics is the study of the complete set of RNA transcripts produced by the genome under specific circumstances or in a specific cell. It helps scientists understand which genes are active, how they are regulated, and how their expression changes in different conditions, such as in diseases like alopecia.

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Comprehensive Transcriptome Data to Identify Downstream Genes of Testosterone Signaling in Dermal Papilla Cells

research Comprehensive transcriptome data to identify downstream genes of testosterone signalling in dermal papilla cells

November 2022 in “Scientific Data”

The research identified genes and non-coding RNAs in cells that could be affected by testosterone, which may help understand hair loss and prostate cancer.

research Integrative analysis of Iso-Seq and RNA-seq data reveals transcriptome complexity and differential isoform in skin tissues of different hair length Yak

5 citations , May 2024 in “BMC Genomics”

Different genes affect hair length in yaks.

Inferring Spatially Resolved Transcriptomics Data from Whole Slide Images for the Assessment of Colorectal Tumor Metastasis: A Feasibility Study

research Inferring Spatially Resolved Transcriptomics Data from Whole Slide Images for the Assessment of Colorectal Tumor Metastasis: A Feasibility Study

November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Using deep learning to predict gene expression from images could help assess colorectal cancer metastasis.

research Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens

2 citations , February 2025 in “Poultry Science”

TBX5 gene influences feathered feet in Guangxi chickens by affecting cell growth and movement.

research Diagnosis of childhood and adolescent growth hormone deficiency using transcriptomic data

1 citations , February 2023 in “Frontiers in Endocrinology”

Childhood growth hormone deficiency can be accurately diagnosed using gene expression data and random forest analysis.

Glucoraphanin and Sulforaphane Biosynthesis Mediated by Melatonin and Nitric Oxide in Hairy Roots of Broccoli: Insights from Transcriptome Data

research Glucoraphanin and sulforaphane biosynthesis by melatonin mediating nitric oxide in hairy roots of broccoli (Brassica oleracea L. var. italica Planch): insights from transcriptome data

1 citations , August 2022 in “BMC Plant Biology”

Melatonin helps broccoli roots produce anti-cancer compounds by controlling nitric oxide and hydrogen peroxide levels.

research The fiber diameter traits of Tibetan cashmere goats are governed by the inherent differences in stress, hypoxic, and metabolic adaptations: an integrative study of proteome and transcriptome

17 citations , March 2022 in “BMC Genomics”

Cashmere fiber diameter in Tibetan goats is influenced by their stress, oxygen, and metabolic adaptations.

research Integration Analysis of Hair Follicle Transcriptome and Proteome Reveals the Mechanisms Regulating Wool Fiber Diameter in Angora Rabbits

March 2024 in “International journal of molecular sciences”

The research identified key proteins that affect wool fiber thickness in Angora rabbits.

Identifying Molecular Targets for Reverse Aging Using Integrated Network Analysis of Transcriptomic and Epigenomic Changes During Aging

research Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging

12 citations , June 2021 in “Scientific Reports”

Curcumin may help reverse aging by targeting specific genes.

research Plasma proteome–driven identification of druggable immune regulators of alopecia areata, validated by transcriptome and single-cell mapping

March 2026 in “Skin Appendage Disorders”

Belatacept may be a promising treatment for alopecia areata.

research Prioritizing Susceptibility Genes for the Prognosis of Male-pattern Baldness with Transcriptome-wide Association Study

January 2024 in “Research Square (Research Square)”

The research identified genes linked to male-pattern baldness and potential drug targets for treatment.

research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

8 citations , March 2023 in “International Wound Journal”

IGF2BP3 and other m6A-related genes are linked to keloid formation and could be potential treatment targets.

research Application of multi-omics techniques to androgenetic alopecia: Current status and perspectives

June 2024 in “Computational and Structural Biotechnology Journal”

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

January 2023 in “Research Square (Research Square)”

IGF2BP3 gene is up-regulated in keloid patients, suggesting potential targets for treatment.

research Significance of stress keratin expression in normal and diseased epithelia

47 citations , January 2024 in “iScience”

Stress keratins are expressed less in diseased skin and are linked to differentiation, inflammation, and immunity.

research 891 Comparison of phenotypes and transcriptomes of mouse skin-derived precursors and dermal mesenchymal stem cells

April 2019 in “Journal of Investigative Dermatology”

The search scheme SMRI is faster and more secure for retrieving encrypted data from the cloud.

research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

13 citations , September 2022 in “Biomolecules”

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.

Supplementary Material for: Plasma Proteome–Driven Identification of Druggable Immune Regulators of Alopecia Areata, Validated by Transcriptome and Single-Cell Mapping

research Supplementary Material for: Plasma proteome–driven identification of druggable immune regulators of alopecia areata, validated by transcriptome and single-cell mapping

March 2026 in “Figshare”

CD28 is a promising target for treating alopecia areata with belatacept.

research Supplementary Material for: Plasma proteome–driven identification of druggable immune regulators of alopecia areata, validated by transcriptome and single-cell mapping

March 2026 in “Figshare”

CD28 is a promising target for treating alopecia areata with belatacept.

research 83 Transcriptomic meta-analysis and deconvolution approaches unveil cellular dynamics in scarring and non-scarring primary lymphocytic alopecias

November 2023 in “Journal of Investigative Dermatology”

Different types of hair loss have unique cellular changes, suggesting new treatment targets.

research Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

June 2024

Spaceflight can harm skin health, but organisms can adapt after returning to Earth.

research Transcriptome-based selection and validation of optimal house-keeping genes for skin research in goats (Capra hircus)

23 citations , July 2020 in “BMC Genomics”

NCBP3, SDHA, and PTPRA are the best genes for accurate goat skin research.

research Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

7 citations , June 2024 in “Communications Medicine”

Spaceflight can harm skin health by altering gene expression, affecting DNA, mitochondria, and skin barriers.

Systems Pharmacology Identifies Dermal Papilla-Specific Transcriptomic Reversal of Androgenetic Alopecia by Lithium-Zinc Pathway Convergence

research Systems pharmacology identifies dermal papilla–specific transcriptomic reversal of androgenetic alopecia by lithium–zinc pathway convergence

March 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Lithium and zinc together may help reverse hair loss by targeting specific cells.

research Systems pharmacology identifies dermal papilla–specific transcriptomic reversal of androgenetic alopecia by lithium–zinc pathway convergence

March 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Lithium and zinc together can reverse hair loss by targeting specific cells.

research Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study

April 2024 in “Human genomics”

Identified genes linked to male-pattern baldness may help develop new treatments.

research Transcriptome meta-analysis reveals the hair genetic rules in six animal breeds and genes associated with wool fineness

10 citations , June 2024 in “Frontiers in Genetics”

Different sheep breeds share similar genetic factors affecting wool fineness.

Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus

research 1616 Cross-comparison of inflammatory skin disease transcriptomics identifies PTEN as a pathogenic disease classifier in cutaneous lupus erythematosus

April 2023 in “Journal of Investigative Dermatology”

PTEN was identified as a specific marker for the skin disease cutaneous lupus erythematosus, and it helps increase the expression of harmful type I interferons.

research Transcriptome Profile at Different Physiological Stages Reveals Potential Mode for Curly Fleece in Chinese Tan Sheep

55 citations , August 2013 in “PloS one”

Genetic differences between young and old Tan sheep explain why their fleece changes from curly to straight as they age.

research Evaluation of noninvasive biospecimens for transcriptome studies

9 citations , December 2023 in “BMC Genomics”

Hair follicles and urine cell pellets are promising for transcriptome studies.