research Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream
The microemulsion delivered the dye deeper into the skin than the cream.
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780-810 / 1000+ resultsresearch Immunization by Application of DNA Vaccine onto a Skin Area Wherein the Hair Follicles Have Been Induced into Anagen-onset Stage
Applying a DNA vaccine to skin with active hair growth boosts immune response and protection against anthrax in mice.
research Drug Delivery with Topically Applied Nanoparticles: Science Fiction or Reality?
Nanoparticles show promise for drug delivery through hair follicles but not through healthy skin.
research Time and depth resolved visualisation of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin
The dye quickly penetrates hair follicles, mainly through the gap, not the surrounding skin.
research High spatial resolution study of human skin using synchrotron infrared microscopy: application to the penetration of external agents
External agents penetrate skin more easily in areas with fewer lipids, especially through hair follicles.
research Fractional microporation-guided delivery of nanoencapsulated drugs for enhanced cutaneous and follicular absorption: a comparison of ablative laser and radiofrequency microneedling
research Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates
A new carrier improves skin delivery of tofacitinib for treating inflammatory skin diseases.
research Characterization of factors that determine lentiviral vector tropism in skin tissue using an ex vivo model
Lentiviral vector effectiveness in skin is influenced by external factors, not receptor availability.
research Trans-Epidermal Elimination Due to Insulin Formulation: Report of a Rare Adverse Effect
Switching insulin brands caused skin lesions in a diabetic woman, resolved by changing to oral medication.
research The extent of the uptake of plasmid into the skin determines the immune responses induced by a DNA vaccine applied topically onto the skin
Better DNA uptake in the skin leads to stronger immune responses.
research Design and synthesis of potential nano-carrier for delivery of diphencyprone to hair follicle
research Clinical Considerations of Bioequivalence for Topical Dermatologic Drugs
Current methods for assessing bioequivalence of topical drugs are limited and lack standardization.
research Effect of Rubbing Application on the Skin Permeation of Active Ingredients from Lotion and Cream
Rubbing skin increases absorption of water-soluble drugs from lotions and creams, but not oil-soluble drugs.
research FORMULATION OF TOPICAL FINASTERIDE AND EVALUATION OF ITS PERCUTANEOUS ABSORPTION
research Measurement of Skin Permeation/Penetration of Nanoparticles for Their Safety Evaluation
Nanoparticles don't penetrate intact skin but can enter through pores or damaged skin.
research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation
TCDD speeds up skin barrier formation by increasing certain gene expressions.
research Tether-induced tenosynovitis: The importance of an intact skin barrier
An intact skin barrier is crucial to prevent infection in cases of tether-induced tenosynovitis.
research Direct quantitative digital autoradiography of testosterone metabolites in the pilosebaceous unit: an environmentally advantageous trace radioactive technology
The method accurately measures testosterone metabolites with high sensitivity and low environmental impact.
research Do nanoparticles have a future in dermal drug delivery?
Nanoparticles can improve drug delivery to hair follicles but struggle to penetrate deeper skin layers.
research Skin Permeation of Small-Molecule Drugs, Macromolecules, and Nanoparticles Mediated by a Fractional Carbon Dioxide Laser: The Role of Hair Follicles
Fractional CO2 laser treatment significantly boosts drug and nanoparticle skin absorption, especially through hair follicles.
research Evaluation of the Hairless Rat as a Model for in Vivo Percutaneous Absorption
Hairless rats absorb substances through their skin more easily than hairy rats.
research Can mesoporous nanoparticles promote bioavailability of topical pharmaceutics?
Smaller mesoporous nanoparticles can improve the effectiveness of topical drugs by penetrating skin furrows.
research Selective follicular targeting by modification of the particle sizes
Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.
research Drug delivery to hair follicles
Optimizing drug delivery to hair follicles is crucial for effective treatment.
research Topical Application of the Synthetic Triterpenoid RTA 408 Protects Mice from Radiation-Induced Dermatitis
RTA 408 cream protects mice from radiation skin damage.
research Determination of topically applied finasteride penetrated into hair follicles by using the differential stripping technique
research Description of the Intrafollicular Delivery of Large Molecular Weight Molecules to Follicles of Human Scalp Skin In Vitro
Properly formulated large molecules can reach active levels at the hair bulb.
research Enhancement of percutaneous absorption of Finasteride by cosolvents, cosurfactant and surfactants
Transcutol P best increases Finasteride absorption for hair loss treatment.
research INTRODUCING ELECTROMAGNETIC ENERGY FROM HYDROCOLLOID WOUND DRESSING PASTE PENETRATING A GLASS BARRIER DISRUPTING HUMAN SKIN LIPID DROPLETS SIZE AND MEMBRANES: POSSIBLE IMPLICATIONS IN CANCER CELLS GENESIS AND/OR CURE
Electromagnetic energy from wound dressing paste can disrupt skin lipid droplets, possibly affecting cancer development.
research Analysis of hair follicle penetration of lidocaine and fluorescein isothiocyanate-dextran 4 kDa using hair follicle-plugging method
Hair follicles are important for the absorption of certain drugs into the skin.