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research The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

344 citations , May 2018 in “EMBO journal”

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

research The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation

March 2026 in “Adipocyte”

Spt4 and Spt6 are essential for fat cell development.

research BMP4 and nuclear laminC orchestrate a expression of AHF/Trichohyalin molecule, a key modulator of keratin intermediate filaments in the hair follicle

January 2007

research The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors

18 citations , November 2005 in “Archives of Dermatological Research”

research The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology

62 citations , December 2007 in “Journal of Cellular and Molecular Medicine”

Kremen is crucial for proper development and preventing tumors by regulating Wnt signaling.

research Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation

2 citations , January 2014 in “Photochemical & photobiological sciences”

Grasp protein helps maintain skin health after UVB exposure.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-associated Protein (KAP) Genes on Chromosome 21q22.1

100 citations , December 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.

research 586 Increase in CD8+ effector memory cells re-expressing CD45RA (TEMRA) reflects disease activity and enables early prediction of therapeutic outcome in rapidly progressive alopecia areata

April 2023 in “Journal of Investigative Dermatology”

Increased TEMRA cells can predict treatment outcomes in rapidly progressive alopecia areata.

research Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients

116 citations , May 1992 in “The American Journal of Medicine”

Flutamide rarely causes liver toxicity in prostate cancer patients.

research Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells

11 citations , February 2018 in “Archives of Pharmacal Research”

Finasteride reduces melanin production, possibly treating hyperpigmentation and melanoma, but needs more safety research.

research 18883 Androgenetic alopecia pattern hair regrowth in patients with alopecia areata treated with oral JAK inhibitors

November 2020 in “Journal of The American Academy of Dermatology”

Oral JAK inhibitors help regrow hair in alopecia patients.

research Characterization of the Role of Transferrin receptor 1 (Tfr1) in the Intestinal Epithelium, Pancreas, and Skin

January 2015 in “DukeSpace (Duke University)”

Transferrin receptor 1 is essential for normal function in the intestines, pancreas, and skin.

research Author response: IL18 signaling promotes homing of mature Tregs into the thymus

July 2020

IL-18 signaling helps mature Tregs move into the thymus.

research TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling.

August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

TLR2, a component in hair follicle stem cells, is crucial for healthy hair growth and regeneration, and its decrease can lead to hair loss.

research Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo

3 citations , January 2022 in “Burns & Trauma”

CTHRC1 helps sweat glands recover by rebuilding nearby blood vessels.

research Novel KRT83 and KRT86 mutations associated with monilethrix

18 citations , January 2015 in “Experimental Dermatology”

New mutations in KRT83 and KRT86 are linked to the hair disorder monilethrix.

research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One

10 citations , July 2022 in “Journal of Medicinal Chemistry”

Adding a second method to PROTACs could improve cancer treatment.

research 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis

1 citations , July 2024 in “Journal of Investigative Dermatology”

TAK-279 effectively reduces psoriasis symptoms and is safe.

research Deletion analysis of AGD1 reveals domains crucial for its plasma membrane recruitment and function in root hair polarity

11 citations , June 2017 in “Journal of cell science”

AGD1's PH domain is essential for its role in root hair growth and polarity.

research Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis

10 citations , August 2013 in “Experimental Dermatology”

Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.

research Characterization of New Members of the Human Type II Keratin Gene Family and a General Evaluation of the Keratin Gene Domain on Chromosome 12q13.13

92 citations , February 2005 in “Journal of Investigative Dermatology”

research Prostanoid receptors in anagen human hair follicles

39 citations , November 2007 in “Experimental dermatology”

Human hair follicles contain a complex network of prostanoid receptors that may influence hair growth.

research Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells

8 citations , June 2001 in “Journal of Biological Chemistry”

A truncated protein linked to breast cancer may change cell adhesion.

research Intermolecular NH2-/Carboxyl-terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

227 citations , January 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

research 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification

1 citations , April 2018 in “Journal of Investigative Dermatology”

PRC1 is essential for proper skin development and stem cell formation by controlling gene activity.

A New Mutation Resulting in the Truncation of the TRAF6-Interacting Domain of XEDAR: A Possible Novel Cause of Hypohidrotic Ectodermal Dysplasia

research A new mutation resulting in the truncation of the TRAF6-interacting domain of XEDAR: a possible novel cause of hypohidrotic ectodermal dysplasia: Figure 1

17 citations , August 2012 in “Journal of Medical Genetics”

A new mutation in the XEDAR gene might cause a rare skin condition called hypohidrotic ectodermal dysplasia.

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