research N-(3,5-Dimethylphenyl)-3-Methoxybenzamide (A3B5) Targets TRP-2 and Inhibits Melanogenesis and Melanoma Growth
A3B5 can reduce skin pigmentation and slow melanoma growth.
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30 / 1000+ resultsresearch Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor
The study investigated the antimelanogenic effects of ginsenoside Rg3 (G-Rg3) from Panax ginseng, known for its antioxidative, antitumorigenic, and anti-inflammatory properties. G-Rg3 significantly inhibited melanin synthesis in normal human epidermal melanocytes and B16F10 cells in a dose-dependent manner by reducing the activity of cellular tyrosinase and the expression of MITF, tyrosinase, and TRP1, while strongly activating ERK. The use of PD98059, an ERK inhibitor, attenuated these effects, indicating that ERK activation is crucial for G-Rg3's antimelanogenic action. The findings suggested that G-Rg3 could be a promising and safe skin-whitening agent, enhancing the cosmetic applications of P. ginseng.
research CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis
CARI ONE helps start hair growth and makes hair follicles bigger and more numerous.
research Location and fine structure of melanocytes in human fetal scalp hair follicles.
Melanocytes in the outer root sheath are likely stem cells that grow fast but stay immature.
research Melanocyte Subpopulation Turnover During the Human Hair Cycle: An Immunohistochemical Study
Melanocyte activity in hair follicles is linked to the hair growth cycle, being active in growth phases and inactive in rest phases.
research Age-induced hair greying - the multiple effects of oxidative stress
Hair greying is caused by oxidative stress damaging hair follicles and melanocytes.
research The Effect of Butin on the Vitiligo Mouse Model Induced by Hydroquinone
Butin is effective in treating vitiligo in mice.
research Efficacy of an agonist ofα-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation
Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.
research Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids
Rice bran extract can increase melanin production and may help treat melanin deficiency.
research Optimization of the method for the culture of melanocyte precursors from hair follicles and their activation by 1,25-dihydroxyvitamin D3
1,25-dihydroxyvitamin D3 helps melanocyte precursors from hair follicles grow and produce melanin, aiding vitiligo treatment understanding.
research Synergistic effect of rice bran extract and extremely low-frequency electromagnetic fields on dermal papilla/melanocytes in melanogenesis
Rice bran extract and low-frequency electromagnetic fields together may help treat vitiligo and white hair.
research Drug Repurposing of Voglibose, a Diabetes Medication for Skin Health
Voglibose may help treat skin hyperpigmentation safely.
research Valorization of Hom Thong Banana Peel (Musa sp., AAA Group) as an Anti-Melanogenic Agent Through Inhibition of Pigmentary Genes and Molecular Docking Study
Hom Thong banana peels can help reduce skin pigmentation by inhibiting melanin production.
research Exploring the potential effect and mechanisms of protocatechuic acid on human hair follicle melanocytes
Protocatechuic acid can reduce melanin production and boost antioxidant activity in hair follicles.
research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport
Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.
research Stimulation of melanogenesis by Carthamus tinctorius floret extract in B16F10 murine melanoma cells
Safflower extract increases melanin production in certain skin cells without harming them.
research Betamethasone actives cultured amelanotic melanocytes derived from outer root sheath of human hair follicle
Betamethasone activates and increases the growth of certain skin cells from hair follicles.
research All-trans retinoic acid induced the differentiation of amelanotic melanocytes of human hair follicle
All-trans retinoic acid helps amelanotic melanocytes in hair follicles develop and produce pigment while reducing their growth.
research A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia
A TP63 gene mutation causes significant hair loss and mild skin, nail, and tooth abnormalities.
research Dormant tumor cells in ret transgenic mouse melanoma model and their interaction with memory T cells
Dormant melanoma cells in mice interact minimally with memory T cells due to a suppressive tumor environment.
research 적하수오 에탄올 추출물의 melanin 합성 촉진효과
PMEE may help reverse greying hair by boosting melanin production.
research TRP Channels in Skin Biology and Pathophysiology
TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
research TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons
TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.
research The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles.
TRPS1 is crucial for bone, kidney, and hair follicle development.
research Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis
Trps1 is essential for proper hair follicle development.
research A frameshift mutation in the TRPS1 gene showing a mild phenotype of trichorhinophalangeal syndrome type 1
A small change in the TRPS1 gene leads to a less severe form of a syndrome affecting hair, nose, and finger development.
research TRPS1 haploinsufficiency results in increased STAT3 and SOX9 mRNA expression in hair follicles in trichorhinophalangeal syndrome
Reduced TRPS1 leads to increased STAT3 and SOX9 in hair follicles, affecting hair growth.
research Molecular studies of transient receptor potential Vanilloid 3 (TRPV3)
TRPV3 channels are involved in skin processes and are affected by shear stress, influencing itch and mechanotransduction.
research The Role of the TRPV4 Channel in Intestinal Physiology and Pathology
Targeting the TRPV4 channel may help treat intestinal diseases.
research The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells
TRF1 is crucial for creating and maintaining stem cells and marks both pluripotent and adult stem cells.