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research Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata

12 citations , March 2016 in “BBA clinical”

Increased Toll-like receptors in blood cells may contribute to alopecia areata and could be a target for new treatments.

research Signaling modality within gp130 receptor enhances tissue regeneration

January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gp130 receptor helps in tissue regeneration and disease progression, and manipulating it could improve healing and prevent disease.

research Regulatory T Cell Heterogeneity in the Steady State and Tumor

January 2026 in “Immune Network”

Regulatory T cells adapt to different environments to control inflammation and support tissue repair.

research Non-Edg family LPA receptors: the cutting edge of LPA research

68 citations , July 2011 in “Journal of Biochemistry/The journal of biochemistry”

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

research p75 Neurotrophin Receptor Antagonist Retards Apoptosis-driven Hair Follicle Involution (Catagen)

24 citations , January 2003 in “Journal of Investigative Dermatology”

Blocking a specific receptor slows down hair loss in mice.

research 1361 A novel cell surface marker for hair follicle dermal cells throughout hair morphogenesis and cycling

April 2018 in “Journal of Investigative Dermatology”

Researchers found that the Leptin receptor is a consistent marker for hair follicle dermal cells, which may help future hair research.

research Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11*1

1 citations , May 2004 in “Biochemical and Biophysical Research Communications”

Two new gene clusters important for hair formation were found on human chromosome 11.

research Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8

61 citations , May 2016 in “Scientific reports”

The peptide IMT-P8 can effectively deliver proteins into the skin and cells for potential skin treatments.

research Author response: Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)

October 2021

CCC1 is essential for pH balance and normal cell function in plants.

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

January 2025

CRH causes hair loss by reducing autophagy and increasing cell death in hair cells.

research Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits

2 citations , May 2024 in “BMC Genomics”

Certain genetic changes in the KRT82 gene may cause patchy skin in New Zealand rabbits.

research A novel monoclonal antibody to the outer root sheath cells

3 citations , October 1994 in “Journal of Dermatological Science”

The new antibody, TYHF-1, specifically targets certain hair-related structures.

research Targeting receptor–regulator interactions

August 2013 in “Nature Reviews Drug Discovery”

New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.

research Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

February 2022 in “Research Square (Research Square)”

High TSPEAR levels in colorectal cancer predict worse outcomes.

research RNase L represses hair follicle regeneration through altered innate immune signaling

November 2025

RNase L hinders hair follicle regeneration by altering immune signals.

research POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS.

January 2020 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)”

Polycomb Repressive Complex 1 is crucial for keeping stem cells stable and maintaining healthy adult tissues.

Large-Scale Skin scRNA-Seq Profiling Highlights Distinct Body Site-Specific Ligand-Receptor Interactions and Pathways in Keratinocytes

research LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes

August 2023 in “Journal of Investigative Dermatology”

Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.

research Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a differentiated phenotype

25 citations , July 1994 in “Journal of Cell Science”

Immortalized rat dermal papilla cells can still induce hair growth.

research 1393 Human TMEM2 is not a hyaluronidase but a regulator of hyaluronan metabolism

April 2023 in “Journal of Investigative Dermatology”

Human TMEM2 does not break down hyaluronan but helps control its metabolism.

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

April 2025 in “Annals of Medicine”

CRH can cause hair loss by promoting cell death in hair growth cells.

research CCDC22 and CCDC93, two potential retriever-interacting proteins, are required for root and root hair growth in Arabidopsis

December 2022 in “Frontiers in plant science”

CCDC22 and CCDC93 are essential for root and root hair growth in Arabidopsis.

CRABP1 Enhances Proliferation of Dermal Papilla Cells in Hu Sheep via Wnt/β-Catenin Pathway

research CRABP1 Enhances the Proliferation of the Dermal Papilla Cells of Hu Sheep through the Wnt/β-catenin Pathway

September 2024 in “Genes”

CRABP1 boosts hair cell growth in Hu sheep by affecting key genes.

research AIMP1-derived peptide secreted from hair follicle stem cells activates dermal papilla cells to promote hair growth

1 citations , February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

A peptide from hair follicle stem cells promotes hair growth by activating specific skin cells.

Successful Topical Minoxidil Treatment for Hair Density and Length in Trichorhinophalangeal Syndrome Type 1

research The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair

46 citations , December 2001 in “Journal of Endocrinology/Journal of endocrinology”

FLRG and follistatin have different roles in wound healing.

Silencing Key Players of Androgenetic Alopecia Pathogenesis in Healthy Human Hair Follicles Ex Vivo Highlights the Hair Growth Inhibitory Effect of SFRP1

research 63452 Silencing key players of androgenetic alopecia pathogenesis in healthy human hair follicles ex vivo highlights the hair growth inhibitory effect of SFRP1

September 2025 in “Journal of the American Academy of Dermatology”

Reducing SFRP1 can promote hair growth and may help treat hair loss.

research A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious Puberty

3 citations , October 2024 in “Advances in Therapy”

Triptorelin effectively treats central precocious puberty in Chinese children with minimal side effects.

research Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways

May 2026 in “Scientific Reports”

Overexpression of LRIG3 in skin causes hair loss.

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Research

research Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata

research Signaling modality within gp130 receptor enhances tissue regeneration

research Regulatory T Cell Heterogeneity in the Steady State and Tumor

research Non-Edg family LPA receptors: the cutting edge of LPA research

research p75 Neurotrophin Receptor Antagonist Retards Apoptosis-driven Hair Follicle Involution (Catagen)

research 1361 A novel cell surface marker for hair follicle dermal cells throughout hair morphogenesis and cycling

research Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11*1

research Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8

research Author response: Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

research Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits

research A novel monoclonal antibody to the outer root sheath cells

research Targeting receptor–regulator interactions

research Increased Expression of TSPEAR in Colorectal Cancer Predicts Poor Prognosis

research RNase L represses hair follicle regeneration through altered innate immune signaling

research POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS.

research LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes

research Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a differentiated phenotype

research 1393 Human TMEM2 is not a hyaluronidase but a regulator of hyaluronan metabolism

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

research CCDC22 and CCDC93, two potential retriever-interacting proteins, are required for root and root hair growth in Arabidopsis

research CRABP1 Enhances the Proliferation of the Dermal Papilla Cells of Hu Sheep through the Wnt/β-catenin Pathway

research AIMP1-derived peptide secreted from hair follicle stem cells activates dermal papilla cells to promote hair growth

research Successful topical minoxidil treatment for hair density and length in trichorhinophalangeal syndrome type 1

research Cellular localization of retinoic acid receptor-gamma expression in normal and neoplastic skin.

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

research The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair

research 63452 Silencing key players of androgenetic alopecia pathogenesis in healthy human hair follicles ex vivo highlights the hair growth inhibitory effect of SFRP1

research A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious Puberty

research Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways