research A review of genotrichoses and hair pathology associated with inherited skin diseases
Next-generation sequencing greatly improves understanding and treatment of genetic hair disorders.
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600-630 / 1000+ resultsresearch Complex X chromosome rearrangement associated with multiorgan autoimmunity
A complex X chromosome rearrangement can increase the risk of multiple autoimmune diseases.
research Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform
Dissolving microneedle patches can effectively deliver drugs over time.
research Intrinsic factors in the pathogenesis of hidradenitis suppurativa: Genetics, hormones, and the microbiome
This review examines the complex pathogenesis of hidradenitis suppurativa (HS), focusing on genetic, hormonal, and microbiome factors. It identifies genetic links to hair follicle stem cell fate and androgen signaling, with inflammation influenced by the cutaneous and gut microbiomes. Hormonal factors, particularly during puberty and pregnancy, and metabolic factors like obesity and insulin resistance, are highlighted as contributors to HS. The review notes the altered microbiome in HS patients and suggests that a combination of therapies targeting hormonal, metabolic, and immunological factors may improve clinical outcomes. However, it emphasizes the need for further research to address unresolved questions about disease predisposition and progression.
research Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex
Sex hormones affect liver fat and metabolic health differently in men and women.
research Investigation of the Mitigation of DMSO-Induced Cytotoxicity by Hyaluronic Acid following Cryopreservation of Human Nucleus Pulposus Cells
Hyaluronic acid reduces cell damage from DMSO in preserved human cells.
research Engineered Dutasteride-Lipid Based Nanoparticle (DST-LNP) System Using Oleic and Stearic Acid for Topical Delivery
The formulation with oleic acid may be better for treating male pattern baldness.
research Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits
The KRTAP21-1 gene affects wool yield and can help improve wool production.
research Ichthyosis hystrix
A rare skin condition with dark, thick, warty patches and some hair loss was found in a newborn boy.
research Prostate volume and its relationship with anthropometric variables among different ethnic groups of South-Kivu, DR Congo
Prostate size varies by ethnic group, age, residence, and blood glucose, but not by body measurements or fat.
research Cutaneous extramedullary haematopoiesis: Implications in human disease and treatment
Skin can produce blood cells, often due to disease, which might lead to new treatments for skin and blood conditions.
research Genetically determined metabolites in allergic conjunctivitis: A Mendelian randomization study
Eight blood metabolites are linked to causing allergic conjunctivitis, offering new ways to predict and treat it.
research Testing the impact of trait prevalence priors in Bayesian-based genetic prediction modeling of human appearance traits
Using trait prevalence priors in genetic prediction models for appearance traits is currently impractical due to limited knowledge and potential accuracy issues.
research Comparative advantage and efficacy of natural products for polycystic ovary syndrome
More research is needed to confirm if natural products effectively treat PCOS.
research Forensic skeletal and molecular anthropology face to face: Combining expertise for identification of human remains
Combining skeletal and molecular anthropology improves identifying human remains.
research Development and Characterization of Dual-Loaded Niosomal Ion-Sensitive In Situ Gel for Ocular Delivery
The gel effectively delivers drugs to the eye, fights bacteria, and protects against oxidative stress.
research Ovine KRT81 Variants and Their Influence on Selected Wool Traits of Commercial Value
KRT81 gene variations in sheep affect wool weight but not fiber length or thickness.
research The Mean Staple Length of Wool Fibre Is Associated with Variation in the Ovine Keratin-Associated Protein 21-2 Gene
The KRTAP21-2 gene affects wool length and quality in sheep.
research Acrodermatitis enteropathica in the pediatric population: a literature review of real-world studies
Zinc effectively treats most children with acrodermatitis enteropathica, but underlying metabolic issues may require additional management.
research Premature hair graying: a multifaceted phenomenon
Premature hair graying is caused by genetics, stress, and lifestyle, and affects mental health.
research Syndromic epidermolysis bullosa simplex subtype due to mutations in the KLHL24 gene: series of case reports in Russian families
Mutations in the KLHL24 gene cause a skin disorder in some Russian families.
research Immunological and Metabolic Causes of Infertility in Polycystic Ovary Syndrome
PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.
research Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarrier Controls Chemotherapy-Induced Alopecia Areata
A new treatment using nanoparticles can effectively prevent and reduce hair loss caused by chemotherapy.
research Genetic prediction of male pattern baldness based on large independent datasets
New models predict male pattern baldness better than old ones but still need improvement.
research Hair microscopy: an easy adjunct to diagnosis of systemic diseases in children
Hair microscopy is a simple and cost-effective method to help diagnose systemic diseases in children.
research Anorexia nervosa and reproduction: connecting brain to gonads
Anorexia nervosa can harm fertility and increase pregnancy risks.
research Hypertension's 3 Dilemmas and 3 Solutions: Pharmacology of the Kidney in Hypertension
Re-evaluating minoxidil, reducing sodium intake, and addressing arteriolar hypertrophy can improve hypertension management.
research Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs
Genomic prediction can improve breeding strategies for Korean Sapsaree dogs.
research Evaluation of acaricide treatments to experimentally reduce winter tick load on moose
The combination treatment effectively reduced winter tick load on moose.
research Exercise in the management of polycystic ovary syndrome: A position statement from Exercise and Sports Science Australia
Exercise is crucial for managing polycystic ovary syndrome (PCOS) and improving overall health.