Search

for
Search:

Sort by

Research

720-750 / 1000+ results

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

December 2022 in “Scientific Reports”

Compound 4 is a promising treatment for hair loss with low toxicity.

research Type XVII collagen coordinates proliferation in the interfollicular epidermis

124 citations , July 2017 in “eLife”

Type XVII collagen helps control skin cell growth and could be a target for anti-aging treatments.

research The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function

10 citations , August 2021 in “EMBO Reports”

The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.

research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

260 citations , July 2010 in “Cell”

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

research Sebum Free Fatty Acids Enhance the Innate Immune Defense of Human Sebocytes by Upregulating β-Defensin-2 Expression

195 citations , December 2009 in “Journal of Investigative Dermatology”

Free fatty acids in sebum boost skin's defense against acne by increasing antimicrobial peptides.

research Type II Keratins Are Phosphorylated on a Unique Motif during Stress and Mitosis in Tissues and Cultured Cells

80 citations , June 2002 in “Molecular Biology of the Cell”

Type II keratins are uniquely phosphorylated during stress and mitosis, affecting their structure and function.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research Evidence for 1,25-Dihydroxyvitamin D3-independent Transactivation by the Vitamin D Receptor

36 citations , February 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

The vitamin D receptor can work without its usual activating molecule.

research Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2

22 citations , August 2015 in “PloS one”

Keratin from hair binds well to gold and BMP-2, useful for bone repair.

research The importance of basonuclin 2 in adult mice and its relation to basonuclin 1

14 citations , March 2016 in “Mechanisms of Development”

Basonuclin 2 is vital for the development of facial bones, hair follicles, and male germ cells in adult mice, and its absence can lead to dwarfism and abnormal follicles.

research Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats

3 citations , January 2021 in “Oxidative Medicine and Cellular Longevity”

Nrf-2-modified stem cells from hair follicles significantly improve ulcerative colitis in rats.

research Chitosan Nanoparticle-Encapsulated Cordyceps militaris Grown on Germinated Rhynchosia nulubilis Reduces Type II Alveolar Epithelial Cell Apoptosis in PM2.5-Induced Lung Injury

2 citations , January 2025 in “International Journal of Molecular Sciences”

Chitosan-encapsulated Cordyceps militaris reduces lung cell damage from pollution.

Newly Emerging Type B Insulin Resistance During Treatment With Eculizumab for AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder: Fatal Outcome

research Newly emerging type B insulin resistance (TBIR) during treatment with eculizumab for AQP4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD): fatal outcome

1 citations , November 2023 in “Journal of neurology”

A patient with a nerve disorder died from infection complications after developing insulin resistance from a treatment.

research Ex vivo detection of SARS CoV 2 spike protein in human hair follicles and potential link to telogen effluvium

November 2025 in “Scientific Reports”

COVID-19 may cause hair loss by affecting hair follicles.

research Chemical Constituents from Osmanthus fragrans var. aurantiacus Makino with Their In Vitro and In Silico Studies Target Anti-Inflammation by Suppressing ERK 1/2 MAPK Signaling

August 2025 in “International Journal of Molecular Sciences”

Osmanthus fragrans var. aurantiacus Makino may help treat inflammation due to its antioxidative and anti-inflammatory properties.

Peer Review of Establishment of an Immortalized Mouse Dermal Papilla Cell Strain with Optimized Culture Strategy

research Peer Review #2 of "Establishment of an immortalized mouse dermal papilla cell strain with optimized culture strategy (v0.1)"

January 2018

The review suggested the study needed to clarify its purpose, compare with non-immortalized cells, and provide more details on methods.

research Peer Review #2 of "Establishment of an immortalized mouse dermal papilla cell strain with optimized culture strategy (v0.2)"

January 2018

Researchers improved mouse skin cell culture methods and created a similar immortal cell line, but need to clarify their methods and benefits.

research Suppression of Vitamin D Receptor and Induction of Retinoid X Receptor α Expression During Squamous Differentiation of Cultured Keratinocytes

15 citations , March 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.

research Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion

1 citations , July 2025 in “Journal of Human Immunity”

Minoxidil helps restore thymus size in 22q11.2 deletion syndrome.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research Characterization of a 300 kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain

77 citations , March 2000 in “Journal of Investigative Dermatology”

The research identified six functional hair keratin genes and four pseudogenes, providing insights into hair formation and gene organization.

research Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles

60 citations , December 2003 in “Journal of Investigative Dermatology”

K6hf is found in specific parts of hair follicles, nails, and tongue, and is linked to hair growth and structure.

research A Splice Site Mutation in the Gene of the Human Type I Hair Keratin hHa1 Results in the Expression of a Tailless Keratin Isoform

28 citations , December 1997 in “Journal of Biological Chemistry”

A genetic mutation in the hHa1 gene creates a smaller, but still functional, hair protein without causing hair problems.

research Plasma-Polymerised Antibacterial Coating of Ovine Tendon Collagen Type I (OTC) Crosslinked with Genipin (GNP) and Dehydrothermal-Crosslinked (DHT) as a Cutaneous Substitute for Wound Healing

6 citations , March 2023 in “Materials”

The GNP crosslinked scaffold with antibacterial coating is effective for rapid wound healing and infection prevention.

research Enrichment and Characterization of Human Dermal Stem/Progenitor Cells by Intracellular Granularity

10 citations , January 2013 in “Stem Cells and Development”

Scientists identified a unique type of human skin stem cell that could help with tissue repair.

research SARS-CoV-2 Infection and Alpha-Synucleinopathies: Potential Links and Underlying Mechanisms

4 citations , November 2024 in “International Journal of Molecular Sciences”

COVID-19 may worsen Parkinson's disease by affecting certain brain proteins.

Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

research Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

3 citations , September 2021 in “International Journal of Molecular Sciences”

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

research Androgen Levels Do Not Predict PCOS Phenotypes in Adolescents and Young Adults

March 2012 in “Journal of Pediatric and Adolescent Gynecology”

Androgen levels do not determine the type of PCOS symptoms in young females.

research PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment

75 citations , September 2016 in “EMBO journal”

PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.

← Previous page Next page →