March 2020 in “Journal of evolution of medical and dental sciences” Male pattern baldness, especially the vertex type, could be an early sign of cardiovascular risk factors like high cholesterol and diabetes.
1 citations
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January 2026 Use personalized cosmeceuticals for safe, effective hair and scalp treatment.
187 citations
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May 1988 in “Differentiation” Trichocytic cytokeratins are found in hair, nails, tongue, and thymus cells, showing complex regulation in tissue development.
92 citations
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June 2005 in “Journal of Investigative Dermatology” All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.
44 citations
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October 2017 in “British Journal of Dermatology” Botulinum toxin has potential for treating various skin conditions and improving wound healing.
40 citations
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September 2004 in “Biomacromolecules” The Glu413Lys mutation in keratin affects hair stability, while Glu413Asp does not.
12 citations
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June 2013 in “Gene” Researchers found genes that affect hair growth in Yangtze River Delta white goats.
6 citations
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September 2012 in “Clinical Interventions in Aging” Honokiol might help reduce male skin aging by maintaining testosterone levels.
3 citations
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November 2018 in “Journal of cellular physiology” Serenoa repens and N-acetyl glucosamine/milk proteins complex may help with hair growth and prevent hair loss.
2 citations
,
January 2002 in “Hormone Research in Paediatrics” Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.
1 citations
,
August 2020 in “Food Research” Plant extracts like Avicennia marina, Boehmeria nipononivea, and Camellia sinensis could potentially treat hair loss with fewer side effects than synthetic drugs.
October 2025 in “Journal of Cosmetic Dermatology” Botulinum toxin Type A helps reduce hypertrophic scars and is generally safe.
September 2025 in “JCEM Case Reports” Consider rare forms of CAH for accurate diagnosis and treatment.
June 2025 in “International Medical Case Reports Journal” Timely diagnosis and treatment of complex autoimmune diseases like APS2 are crucial to prevent complications and improve life quality.
August 2022 in “Journal of Comprehensive Pediatrics” A girl with a rare genetic disorder had a unique bone condition, highlighting the need for careful diagnosis and suggesting the disorder might be more common than thought.
January 2023 in “Skin appendage disorders” Laser treatment for hair loss works equally well on different skin types, but more research is needed for very dark skin.
17 citations
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December 2015 in “BMC Complementary and Alternative Medicine” A new plant extract from Avicennia marina could potentially be used to treat common hair loss.
4 citations
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November 2022 in “Frontiers in endocrinology” The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.
4 citations
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August 2019 in “General and Comparative Endocrinology” Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.
218 citations
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December 2011 in “Advances in Urology” The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
119 citations
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August 2010 in “Journal of Investigative Dermatology” Increased 11β-HSD1 activity in skin may contribute to aging and could be targeted to reduce aging effects.
57 citations
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August 2003 in “British Journal of Dermatology” Minoxidil and pyrithione zinc combo most effectively increases hair density.
54 citations
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May 2015 in “Endocrinology” Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.
53 citations
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January 2017 in “Skin appendage disorders” Botulinum toxin shows promise for various skin conditions but requires more research for confirmation and standardized use.
41 citations
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October 2019 in “Biomolecules” Retinoic acid can either maintain stem cells or make them specialize, depending on the cell type.
20 citations
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January 2017 in “Nutrition Research and Practice” Corn silk extract helps reduce prostate enlargement symptoms.
14 citations
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September 2023 in “Foods” Microfluidics can create precise, efficient delivery systems for food and cosmetics, but scaling up is challenging.
12 citations
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June 2019 in “Psychoneuroendocrinology” Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.
7 citations
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August 2017 in “Journal of dermatological science” Sorafenib causes skin reactions by increasing the number and activity of skin mast cells.