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GlossaryType I Collagen

most abundant protein in skin, bones, and tendons

Type I Collagen is the most abundant collagen in the human body, making up about 90% of the collagen found in skin, bones, tendons, and other connective tissues. It provides structural support and strength, playing a crucial role in wound healing and maintaining the integrity of various tissues.

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research Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle.

45 citations , August 1992 in “PubMed”

The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.

research The distributions of type IV collagen .ALPHA. chains in basement membranes of human epidermis and skin appendages

36 citations , January 2007 in “Archives of Histology and Cytology”

Type IV collagen chains vary in different parts of human skin, with specific patterns linked to melanocytes.

research Expression of laminin, type IV collagen and fibronectin molecules is related to embryonal skin and epidermal appendage morphogenesis.

10 citations , January 2001 in “PubMed”

Laminin, type IV collagen, and fibronectin help develop skin and hair structures in embryos.

research Enrichment and characterization of human dermal stem/progenitor cells using collagen type IV

11 citations , June 2012 in “Journal of Dermatological Science”

Scientists identified a group of human skin cells with high growth and regeneration potential.

research Basement membrane Laminin and Type IV Collagen in Various Benign and Malignant Adnexal Tumors of the Skin: An Immunohistochemical Study

28 citations , October 1984 in “Journal of Investigative Dermatology”

research Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts

11 citations , August 1995 in “Journal of Investigative Dermatology”

research Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified

125 citations , August 1992 in “Development”

Implanted dermal papillae can induce hair growth in rat ear wounds.

research Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

56 citations , December 1990 in “Differentiation”

Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.

research A New Method for Culturing Human Hair Follicle Cells on Floating Mixed Collagen Membranes

6 citations , January 1990 in “The Journal of Dermatology”

Human hair follicle cells can be grown successfully on floating collagen membranes without extra support.

research The 800-nm diode laser irradiation induces skin collagen synthesis by stimulating TGF-β/Smad signaling pathway

59 citations , September 2011 in “Lasers in Medical Science”

The 800-nm laser boosts skin collagen production, improving skin structure.

Design of an Artificial Skin. IV. Use of Island Graft to Isolate Organ Regeneration from Scar Synthesis and Other Processes Leading to Skin Wound Closure

research Design of an artificial skin. IV. Use of island graft to isolate organ regeneration from scar synthesis and other processes leading to skin wound closure

13 citations , March 1998 in “Journal of Biomedical Materials Research”

Island grafts can help study skin regeneration separately from other healing processes.

research Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation

56 citations , November 2003 in “Journal of Investigative Dermatology”

MMP-19 may worsen skin diseases by affecting skin growth and inflammation.

research Expression of basement membrane components through morphological changes in the hair growth cycle

53 citations , April 1985 in “Developmental Biology”

Fibronectin and other basement membrane components increase during hair growth and decrease during rest.

research Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids

14 citations , May 2022 in “Stem cell reports”

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

research Expression of extracellular matrix in hair follicle mesenchyme in alopecia areata

11 citations , December 1990 in “British Journal of Dermatology”

Alopecia areata may involve disrupted mesenchymal function in hair follicles.

research Basement membrane changes in lichen planopilaris

7 citations , June 2009 in “Journal of the European Academy of Dermatology and Venereology”

Basement membrane changes in lichen planopilaris cause scarring and permanent hair loss.

research Effects of extracellular matrix on the growth characteristics of human dermal papillae cellsin vitro

2 citations , July 2016 in “Clinical and Experimental Dermatology”

Some types of extracellular matrix can change how human skin cells grow but don't affect their basic functions.

research Effects of hyperbaric oxygen therapy on rat facial skin

2 citations , March 2015 in “Human & Experimental Toxicology”

Hyperbaric oxygen therapy significantly altered rat facial skin structure.

research Alpaca (Vicugna pacos) Skin Analyzed Under Architecture and Structure

April 2024 in “UNESP Institutional Repository (São Paulo State University)”

Alpaca skin has glands, hair follicles, and different collagen types.

research Acquired curved hair is caused by fusion of multiple hair matrix cells

February 2024 in “Journal of Dermatological Science”

Curved hair can develop when hair cells merge abnormally during growth.

research 130 Expression of nidogen1 in basal cell carcinoma

April 2018 in “Journal of Investigative Dermatology”

Higher levels of nidogen1 and type IV collagen are found in basal cell carcinoma compared to normal skin.

research MicroRNA 조절을 통한 상처 치유 기전에 관한 연구

January 2017

MIR135b affects wound healing by targeting genes, and PDRN may help heal wounds by altering this pathway.

research Enrichment of human hair follicle stem cells by adhering to typeIVcollagen

January 2006

Human hair follicle stem cells can be enriched by sticking to type IV collagen.

research Stem cell factor combined with matrix proteins promotes attachment and migration of amelanotic melanocyte from human follicle hair

January 2006 in “Linchuang pifuke zazhi”

Stem cell factor and certain proteins help melanocytes from hair follicles move and attach better, aiding vitiligo repigmentation.

research The Function and Structure of the Skin

4 citations , November 2014

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

research Expression of the Orphan Protein Plet-1 during Trichilemmal Differentiation of Anagen Hair Follicles

30 citations , February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Plet-1 protein helps hair follicle cells move and stick to tissues.

research [Experimental study on vascular endothelial growth factor 165 gene-modified rat hair follicle stem cells mediated by lentiviral vector].

February 2014 in “PubMed”

Modified rat hair follicle stem cells can help create artificial hair follicles, blood vessels, and skin.

research Hair Follicle Units Improving the Construction of Tissue Engineered Skin in Vitro

January 2013 in “Journal of Tissue Engineering and Reconstructive Surgery”

Inserting hair follicle units improved the development of tissue-engineered skin.

research Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?

13 citations , June 2018 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

Laminin-511 may contribute to psoriasis by affecting skin cell growth and survival.

research Nonviral in Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells

43 citations , September 2009 in “Stem Cells”

A nonviral method was developed to label and culture human hair follicle stem cells.