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GlossaryCollagen Type VII

protein crucial for anchoring skin layers together

Collagen Type VII is a specific type of collagen protein that plays a crucial role in anchoring the outer layer of the skin (epidermis) to the underlying layer (dermis). It forms structures known as anchoring fibrils, which are essential for maintaining skin integrity and preventing blistering. Defects in Collagen Type VII can lead to a genetic condition called dystrophic epidermolysis bullosa, characterized by fragile skin that easily blisters and tears.

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research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

Type VII collagen absence helps skin development by allowing tissue remodeling.

research Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells

1 citations , May 2024 in “Journal of Dermatological Science”

Injecting specific cells into the skin can help improve skin structure and reduce blisters in a genetic skin disorder.

research 1327 Effect of ginsenoside Rd on dermal epidermal junction in fibroblast

April 2018 in “Journal of Investigative Dermatology”

Ginsenoside Rd may help improve skin aging by increasing collagen in the skin.

research Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids

14 citations , May 2022 in “Stem cell reports”

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

research Basement membrane changes in lichen planopilaris

7 citations , June 2009 in “Journal of the European Academy of Dermatology and Venereology”

Basement membrane changes in lichen planopilaris cause scarring and permanent hair loss.

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community Short Peptides for Hair Loss: anyone tried any of these?

in Research/Science 12 upvotes 3 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Age-linked hair loss caused by disappearing collagen, researchers say

56 upvotes 6 years ago

Age-linked hair loss is linked to disappearing collagen. Treatments discussed include minoxidil, finasteride, RU58841, tretinoin, microneedling, and collagen supplements.

community Collagen/Vitamins/Supplements and skin-care routine while on Minoxidil?

in Minoxidil 27 upvotes 5 years ago

Minoxidil users discuss skin-care routines to counteract side effects like dark circles and dull skin. Recommendations include vitamin C, potassium, collagen, retinol, nizoral shampoo, and emu oil.

community Anyone has experienced Collagen Synthesis with min ? (wrinkles, dark circles...)

in Question 11 upvotes 7 years ago

Minoxidil may cause wrinkles and dark circles, which some users report can be mitigated by adjusting dosage. Reactions vary, and while some dismiss these side effects, others experience significant changes.

community 5 months on Fin 1 mg + biotin collagen daily supplement I think this is progress but idk and pls help me get more

in Is this regrowth? 4 upvotes 4 months ago

The user has been using 1mg finasteride and biotin-collagen supplements for 5 months, noticing some progress in hair regrowth. They also use various oils and shampoos, plan to start oral minoxidil, and seek advice on improving their hair care routine.

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