Search

everythinglearnresearchcommunity

for

Search:↓

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

The traditional herbal formulas Yongdamsagan-Tang and Paljung-san, along with the drug finasteride, can reduce inflammation and may work together without affecting each other's effectiveness against benign prostatic hyperplasia.

Researchers found potential urine markers for polycystic ovary syndrome, including testosterone-glucuronide and 11α-hydroxyprogesterone, which may help diagnose the condition.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Vitamin D may help regulate cholesterol and influence prostate cancer development.

Extracellular vesicles could help tailor drug treatments, but more research is needed.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

Genetic differences affect breast cancer treatment success with tamoxifen in South African patients.

Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.

Father's finasteride use may affect son's fertility and testicular function.

Ritlecitinib is approved in the USA and Japan for treating severe hair loss in people aged 12 and older.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Glutathione helps Arabidopsis roots adapt to low phosphate by regulating a specific growth pathway.

Improved delivery methods can enhance mangiferin's effectiveness as a health supplement.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

Pexidartinib often causes liver issues and fatigue, especially in women.

Rodent models of PCOS show some hormone changes similar to humans, but also have key differences.

Computational methods can speed up and improve the development and safety of herbal drugs.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Bicalutamide effectively treats prostate cancer but needs careful monitoring for side effects.

EtG in hair can help detect alcohol use but may be inaccurate in people with certain health conditions.