February 1999 in “The anatomical record” Two mouse mutants have defective hair cuticle cross-linking.
12 citations
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September 2013 in “BMC Biophysics” Keratin filaments' elasticity is influenced by their terminal domains and surrounding medium.
438 citations
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October 2010 in “Oncogene” Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.
38 citations
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February 1988 in “Molecular and Cellular Biology” Only one of the two K16 genes on chromosome 17 makes a functional protein for keratin filaments.
January 2005 in “Zhonghua chuangshang guke zazhi” Human hair keratin is a promising material for nerve repair.
19 citations
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May 2008 in “Applied spectroscopy” Human hair has different protein structures in its cuticle and cortex.
11 citations
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April 2022 in “Biophysical Journal” Disulfide bonds in keratin fibers break more easily under stress, especially when wet, affecting fiber strength.
248 citations
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April 1988 in “Differentiation” Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.
Hair germ cells differ from epidermal cells in keratin expression, and specific keratins form after hair differentiation.
2 citations
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January 2011 in “Dental Medicine Research” Keratin 75 might be important in oral cancer progression.
26 citations
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March 1995 in “Differentiation” A rabbit gene important for hair development was identified and detailed.
July 2007 in “Manuals in biomedical research” 287 citations
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July 2001 in “Journal of Cell Science” The study found 65 intermediate filament genes, including new keratins, and suggested updating keratin naming.
5 citations
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June 2008 in “British Journal of Dermatology”
169 citations
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May 2006 in “Genes & Development” Keratin 17 is crucial for normal hair growth by regulating hair cycle transitions with TNFα.
27 citations
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November 2007 in “Genomics” Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.
100 citations
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November 1997 in “Human Genetics” A new mutation in the hHb1 keratin gene is linked to the hair disorder monilethrix.
38 citations
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February 1989 in “Journal of Investigative Dermatology”
April 2017 in “Journal of Investigative Dermatology” Certain mutations in the KLHL24 gene cause a skin disorder by breaking down an important skin protein.
77 citations
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April 2005 in “Journal of Investigative Dermatology” Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.
4 citations
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December 1995 in “Anthropologischer Anzeiger” Family members have similar hair protein patterns, which could be useful for genetic studies.
86 citations
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April 2009 in “Journal of anatomy” Hard skin features like scales, feathers, and hair evolved through specific protein changes in different animal groups.
July 1995 in “Journal of Dermatological Science” 4 citations
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January 2020 in “Genes” The KRTAP21-2 gene affects wool length and quality in sheep.
18 citations
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January 2018 in “Advances in experimental medicine and biology” Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.
5 citations
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November 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” Wnt/β-catenin signaling is important for keeping skin cell attachment structures stable.
28 citations
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April 1988 in “Archives of Dermatological Research” 21 citations
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June 2003 in “Journal of Morphology” Monotreme and marsupial skin proteins show primitive features and species-specific differences compared to placental mammals.
62 citations
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December 2008 in “Journal of structural biology” Hair curvature in Japanese people is linked to specific cell types and filament arrangements in the hair cortex.