47 citations
,
March 2019 in “Journal of immunology research” Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.
13 citations
,
October 2010 in “Seizure” Extended-release valproate effectively reduced seizures and improved quality of life in epilepsy patients over 6 months, with some side effects.
48 citations
,
June 2013 in “Journal of Dermatological Science” Valproic acid may help hair grow and could be a safe treatment for hair loss.
1 citations
,
January 1999 in “The European journal of contraception & reproductive health care” Valette® is an effective birth control pill that also reduces greasy hair and skin.
15 citations
,
May 2006 in “Brain & development” Valproic acid may cause hair loss by reducing biotinidase enzyme activity in rats.
8 citations
,
October 2019 in “The Journal of surgical research/Journal of surgical research” Sodium valproate helps skin healing by affecting GABA and histone deacetylase.
September 2009 in “European journal of paediatric neurology” Biotin supplements did not significantly reduce hair loss in rats on valproic acid.
6 citations
,
April 2013 in “International Journal of Dermatology” Valproic acid helped hair growth in alopecia patient; more research needed.
3 citations
,
October 1976 in “BMJ” Sodium valproate can cause low platelets and hair loss.
June 2021 in “Clinical neuropsychopharmacology and therapeutics” Valproic acid can cause hair color change in older men.
4 citations
,
January 2019 in “PubMed” Low dose valproate in epileptic children mainly causes weight gain and other non-life-threatening side effects.
May 2024 in “Brain disorders” Agmatine may help reduce seizures linked to hormone changes in female rats.
2 citations
,
November 2024 in “AAPS PharmSciTech” Spanlastic formulations improve rivaroxaban's oral anticoagulation efficiency.
11 citations
,
January 2018 in “International journal of trichology” Valproate can cause hair loss and changes in hair appearance, but may help regrow hair when applied topically.
29 citations
,
October 2009 in “Pharmacology Biochemistry and Behavior” June 2014 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” Progesterone and its metabolites can prevent seizures without major side effects.
Sodium valproate improved epilepsy control in most children but often caused weight gain and other mild side effects.
October 2025 in “Actualización en Medicina de Familia” New drugs face challenges due to limited evidence, and safety updates are advised for some existing medications.
February 2025 in “International Journal of Morphology” Vitamin E can reduce the negative effects of valproic acid on hair and skin development.
January 2024 in “Specialty journal of Pharmacognosy Phytochemistry and Biotechnology” Genetic factors may influence how well valproic acid works and its side effects in epilepsy treatment.
May 2021 in “American journal of medical sciences and medicine” Sodium valproate caused vomiting in 20% of children under 2 years old, with other side effects like hair loss and loss of appetite also noted.
Levetiracetam and valproate sodium both reduce seizures when added to lamotrigine, but levetiracetam has fewer side effects.
9 citations
,
January 2022 in “Biology” Male mice are more susceptible to autism-like changes from valproic acid than female mice.
January 2023 in “The Egyptian Journal of Hospital Medicine” Topical Valproic acid and 5% Minoxidil both significantly increase hair count in Female Pattern Hair Loss, with similar side effects.
June 2019 in “Reactions Weekly”
Placenderm® improves scalp elasticity and hair quality safely.
36 citations
,
July 2005 in “Journal of Neuroendocrinology” Blocking certain brain processes reduces mating behavior in female rats.
1 citations
,
September 2024 in “Veterinary Medicine and Science” Afoxolaner effectively treats mange in guinea pigs with one dose.
9 citations
,
January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology” Higher doses of the medication valproate can cause hair loss, which may stop when the dose is lowered or the medication is stopped.
Female rats showed more panic-related behavior than males, influenced by hormonal cycles and certain drugs.