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The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.

MED1 affects skin wound healing differently in young and old mice.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Vitamin D Receptor is crucial for hair follicle shrinkage and cell death, affecting hair growth.

Vitamin D receptor knockout mice have significant motor impairments but no cognitive deficits.

A mutation in the hairless gene speeds up severe itchy skin in mice on a special diet.

Mice without active or present vitamin D receptors maintain normal blood sugar control and islet gene expression when calcium levels are normal.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

MED1 is essential for normal hair growth and maintaining hair follicle stem cells.

Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.

The mutation causes hairless mice due to mislocalized and dysfunctional HR protein.

Vitamin D3 and its receptor help protect skin from UVB-related cancer.

VDR regulation varies by tissue and is crucial for its biological functions.

The vitamin D receptor is essential for skin stem cells to grow, move, and become different cell types needed for skin healing.

The HR protein's role as a repressor is essential for controlling hair growth.

Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

Hormones significantly affect hair growth and loss, with potential for new treatments.

Vitamin D receptor is crucial for healthy hair growth and preventing hair loss.

Vitamin D and calcium are essential for effective wound healing and hair growth.

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

Vitamin D receptor may help protect against UV-induced skin cancer.

Vitamin D receptor is crucial for skin wound healing.

Deleting MED1 in skin cells causes hair loss and skin changes.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

The R343H mutation in the VDR gene causes vitamin D-resistant rickets with alopecia by impairing specific gene activity.

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.