173 citations
,
May 2001 in “Human reproduction update” Oestrogens are key for bone growth during puberty in both boys and girls.
20 citations
,
May 1998 in “PEDIATRICS” African-American girls tend to start puberty earlier than white girls, possibly due to increased androgen production.
3 citations
,
October 2024 in “The Journal of Clinical Endocrinology & Metabolism” Potential androgen excess signs vary by demographics and health, needing inclusive evaluation.
98 citations
,
July 2011 in “Fertility and Sterility” An mFG score of 5 or more indicates above-normal hair growth in Southern Chinese women.
1 citations
,
September 2019 in “Steroids” Two new mutations in the AR gene linked to severe androgen insensitivity were found.
1 citations
,
January 2021 in “Prague medical report” Men might have a version of the female disease, polycystic ovarian syndrome, shown by changes in hormone levels and early baldness, but more research is needed to fully understand it.
1 citations
,
May 2023 in “Fertility and sterility” Men who went through puberty later had lower sperm counts and altered hormone levels, possibly affecting fertility.
21 citations
,
February 2016 in “Reproductive Biomedicine Online” The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.
January 2016 in “Journal of SAFOG” Girls with PCOS and menstrual disorders have notably higher androgen hormone levels.
January 2025 in “BMJ Case Reports” Precocious puberty can signal familial adenomatous polyposis.
16 citations
,
February 2014 in “Iranian Red Crescent Medical Journal” Polycystic Ovary Syndrome (PCOS) affects Iranian women's feelings of femininity and self-image.
August 2025 in “Journal of Pediatric Endocrinology and Metabolism” A rare ovarian tumor in a 2-year-old girl was successfully removed, normalizing her hormone levels.
6 citations
,
December 2015 in “JAMA” The woman's high testosterone levels indicated PCOS, leading to treatment that improved her symptoms.
November 2012 in “Experimental and Clinical Endocrinology & Diabetes” A new genetic mutation causes severe Leydig cell hypoplasia, affecting sexual development.
70 citations
,
April 2014 in “Annales d'endocrinologie” New genes and pathways are important for testosterone production and male sexual development.
January 2017 in “Springer eBooks” Understanding genes and hormones is crucial for managing male puberty and sex development disorders.
December 2022 in “International Journal of Health Science” High levels of male hormones in women with PCOS can lead to fertility issues and symptoms like irregular periods, hair growth, acne, and hair loss; lifestyle changes are recommended for management.
131 citations
,
September 2010 in “The Laryngoscope” Forehead modification greatly increases the perception of femininity and is a safe procedure.
2 citations
,
October 2020 in “Annals of Oncology” Men may be more vulnerable to severe COVID-19 due to genetic and hormonal factors, but more research is needed.
July 2020 in “Endocrine practice” A 13-year-old boy with Cushing syndrome has high cortisol levels from a pituitary gland issue and underdeveloped sexual characteristics.
March 2023 in “Bagcılar medical bulletin” A young woman had a rare tumor causing high male hormone levels and symptoms like excessive hair and acne. After removing the tumor, her hormone levels returned to normal. Early diagnosis is important.
January 2026 in “Immunological Reviews” Females generally have stronger immune responses than males due to the X chromosome.
22 citations
,
January 2019 in “Endocrinology and metabolism” An mFG score of 7 or higher indicates hirsutism in Filipino women, often linked to higher free testosterone levels.
48 citations
,
February 2006 in “Molecular and Cellular Endocrinology” 5α-reductase inhibitors may reduce male fertility and could be used for male contraception.
441 citations
,
May 2008 in “British Journal of Pharmacology” Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.
284 citations
,
February 2008 in “Pediatrics” Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.
282 citations
,
October 2006 in “The Journal of Clinical Endocrinology and Metabolism” The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.
100 citations
,
July 2004 in “The Journal of Sexual Medicine” Hormones like estrogen, testosterone, progesterone, and prolactin play complex roles in female sexual function, with testosterone potentially improving sexual desire, arousal, and satisfaction. However, more research is needed to establish safe and effective hormone treatments for female sexual dysfunction.
86 citations
,
May 2013 in “American journal of obstetrics and gynecology” Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.