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Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

72 citations , July 2012 in “Journal of Investigative Dermatology”

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

research p53 Involvement in the Control of Murine Hair Follicle Regression

71 citations , June 2001 in “American Journal of Pathology”

The p53 protein helps control hair follicle shrinking by promoting cell death in mice.

research Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis

70 citations , December 2008 in “Cancer Research”

CXCR2 in skin cells promotes tumor growth.

research Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44

68 citations , November 2012 in “Journal of Investigative Dermatology”

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

research Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets due to a Mutation Causing Multiple Defects in Vitamin D Receptor Function

67 citations , August 2004 in “Endocrinology”

A specific gene mutation causes vitamin D resistance, but certain vitamin D analogs might help.

research A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification

66 citations , October 2002 in “Human molecular genetics online/Human molecular genetics”

A gene mutation in mice causes skin defects and early death.

research Dynamics of Merkel Cell Patterns in Developing Hair Follicles in the Dorsal Skin of Mice, Demonstrated by a Monoclonal Antibody to Mouse Keratin 8

64 citations , January 1995 in “Cells Tissues Organs”

Merkel cells develop independently of nerves and are linked to specific hair follicles in mice.

Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues Alopecia in Vitamin D Receptor Null Mice

research Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues the Alopecia in Vitamin D Receptor Null Mice

57 citations , April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D receptor is crucial for starting hair growth after birth.

research Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex

55 citations , November 2018 in “American journal of human genetics”

Mutations in the LSS gene cause a rare type of hereditary hair loss.

research Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice

55 citations , October 2008 in “American Journal Of Pathology”

mIGF-1 in skin cells speeds up wound healing and hair growth in mice without harmful effects.

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