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Ketoconazole increases finasteride's effectiveness and lifespan in the body.

Pharmacophore models can predict liver toxicity and central nervous system toxicity, but they have limitations and specific requirements.

Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

Pesticides can cause reproductive and adrenal health issues.

Epristeride's metabolism involves key metabolites and proteins, affecting its use in doping tests.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Many drugs can cause lipid metabolism issues, and labels need better warnings.

Enzymes play crucial roles in metabolism, health, and disease management.

Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.

Food intake, not genetics, affects how the body processes tadalafil and finasteride.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Targeting lipid metabolism can help treat advanced, resistant cancers.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The weight loss drug Orlistat can cause liver damage and should be used with caution, especially in those with liver or kidney issues.

Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.

Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.

Metabolite 7 is a strong inhibitor for Alzheimer's disease management.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Canine hair follicle cells convert progesterone into various metabolites, mainly cortisol.

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

The study created a new method to test drugs that affect hormone processing in skin.

Integrating biological networks improves drug repurposing and ADR prediction.

The ABCG2 gene variant increases the risk of high uric acid and cholesterol, especially in overweight or obese young Mexican males.