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Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

New inhibitors may reduce gut toxicity from cancer drugs.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

Scientists improved an enzyme to better produce a hair growth-promoting chemical from an immunosuppressant.

The study created a new method to test drugs that affect hormone processing in skin.

Old drugs are often used for new, different medical purposes in endocrine pharmacology.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

Pesticides can cause reproductive and adrenal health issues.

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

Some bacteria use arsenic compounds as antibiotics, and others have evolved resistance; a particular arsenic-based compound shows potential as a new antimalarial treatment.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

Metabolism plays a key role in determining stem cell fate.

Ginsenoside compound K shows promise for treating metabolic diseases like diabetes and obesity.

The model and estimator can predict drug exposure in kidney transplant patients well.

Integrating biological networks improves drug repurposing and ADR prediction.

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

Enobosarm significantly increased muscle mass and improved physical function in elderly men and postmenopausal women without serious side effects.

Understanding genetic traits can help doctors create personalized detox and nutrition plans to boost antioxidant protection.

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

Targeting lipid metabolism can help treat advanced, resistant cancers.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.

Finasteride's metabolites were identified, helping understand how the drug is processed in the body.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Green algae can break down finasteride, reducing environmental harm.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.