research Scarless wound healing: Transitioning from fetal research to regenerative healing
Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.
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research Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue
Transplanting growing hair follicles into scars can help regenerate and improve scar tissue.
research Retinoids in scarless skin regeneration: from molecular mechanisms to therapeutic strategies
Retinoic acid may help heal skin without scars by reducing fibrosis and supporting skin regeneration.
research Building a Better Scar: Re-engineering Extracellular Matrix Structure in Dermal Scars
αCT1 improves scar appearance by changing early collagen structure.
research An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys)
A specific molecular switch, driven by MAPK/ERK signaling, helps spiny mice heal wounds by regenerating skin instead of forming scars.
research Implanted hair-follicle-associated pluripotent (HAP) stem cells differentiating to keratinocytes, macrophages and endothelial cells accelerated cutaneous wound closure and suppressed scar formation in a mouse model
Implanted special stem cells from hair follicles helped heal wounds faster and with less scarring in mice.
research Therapeutic potential of endogenous stem cells and cellular factors for scar-free skin regeneration
Using skin stem cells and certain molecules might lead to scar-free skin healing.
research Treatment of Acne Scar Contraction Using Autologous Cultured Epithelial Sheet Transplantation: A Report of Four Cases
Transplanting cultured skin sheets improved acne scars in four patients.
research Cutaneous Response to Injury and Wound Healing
Wound healing involves three phases and various cells and factors, with scars typically forming in adults. Chronic wounds can occur due to various issues, and abnormal scarring can lead to hypertrophic or keloid scars. Emerging research areas include the role of proteins, microRNAs, macrophage manipulation, and stem cell treatment.
research Cutaneous wound healing: recruiting developmental pathways for regeneration
Understanding developmental pathways can improve wound healing treatments.
research Scarring Alopecia
research Inhibition of Wnt/β‐catenin pathway promotes regenerative repair of cutaneous and cartilage injury
Blocking the Wnt/β‐catenin pathway can speed up wound healing, reduce scarring, and improve cartilage repair.
research Hair-follicle-associated pluripotent (HAP) stem-cell-sheet implantation accelerates cutaneous wound closure and suppresses scar formation in a mouse model
HAP stem cell sheets speed up wound healing and reduce scarring.
research Treating Scars: Addressing Surface, Volume, and Movement to Expedite Optimal Results. Part 2: More-Severe Grades of Scarring
Severe scars need a mix of treatments for best results.
research Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways
IL10_ApoEVs improve skin healing and reduce scarring.
research Prevention and treatment of linear scar formation in the scalp: Basic principles of the mechanism of scar formation
New suturing technique with wider intervals and shallow stitches helps prevent scalp scars and promotes hair growth.
research Cytoskeletal Regulation of Dermal Regeneration
Targeting the actin cytoskeleton could improve skin healing and reduce scarring.
research Fetal Fibroblast Transplantation via Ablative Fractional Laser Irradiation Reduces Scarring
The treatment combining laser and fetal fibroblasts effectively reduces scarring.
research 1454 Identification of Fetuin A as a potential modulator of scar formation
Fetuin A may increase collagen production and promote scarring.
research Following fibroblast lineages in dermal development and scars
N-Cadherin is crucial in scar formation, offering potential for scar prevention therapies.
research Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions
New effective scar treatments are urgently needed due to the current options' limited success.
research β-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding [RETRACTED]
The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.
research Improving Posttraumatic Facial Scars
The document concludes that improving the appearance of posttraumatic facial scars is possible with careful treatment and realistic expectations.
research Polysulfonic acid mucopolysaccharide exerts anti scarring effect in rats through modulation of TGF β 1/Smad signaling pathway
Polysulfonic acid mucopolysaccharide can reduce skin scarring.
research Modern strategies for the prevention and treatment of post-burn scars (a systematic review)
Combining surgical and nonsurgical methods is key to reducing post-burn scars.
research 0977 Pathogenic hallmarks of primary lymphocyte-mediated scarring alopecia revealed by single nuclear and spatial multiomics
Scarring alopecia involves increased immune cells and specific gene changes near damaged hair follicles.
research Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars
Inflammatory acne damages skin stem cells and reduces their growth, leading to atrophic acne scars.
research Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.
research LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes
Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.
research Diverse cellular players orchestrate regeneration after wounding
Different cell types work together to repair skin, and targeting them may improve healing and reduce scarring.