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GlossarySensitization

immune system becomes overly reactive to a substance

Sensitization refers to the process by which the immune system becomes overly reactive to a substance, often leading to allergic reactions. For example, in the context of hair and scalp health, repeated exposure to certain hair dyes or chemicals can cause the immune system to recognize these substances as harmful, resulting in inflammation or allergic dermatitis upon subsequent exposures.

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Research

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research Acute dermal and ocular irritation testing of rice bran supercritical CO2 extract (RB-SCE) and 0.5% RB-SCE essence product

2 citations , March 2015 in “Toxicology and Environmental Health Sciences”

Rice bran extract caused moderate skin irritation but no eye irritation, while a diluted essence was not irritating to skin and only slightly to guinea pigs.

Herbal Lotions to Regrow Hair in Patients with Intractable Alopecia Areata

research Herb lotions to regrow hair in patients with intractable alopecia areata

2 citations , January 2017 in “Clinical and medical investigations”

Herbal lotions are effective for severe hair loss, with a 64.8% success rate, but relapse is common and long-term management requires allergen control and possible corticosteroid use.

research An Animal Model of Trichloroethylene-Induced Skin Sensitization in BALB/c Mice

36 citations , June 2015 in “International journal of toxicology”

Trichloroethylene causes skin inflammation in mice by increasing certain immune proteins.

research Indications for Peripheral and Central Sensitization in Patients With Chronic Scalp Pain (Trichodynia)

16 citations , December 2012 in “The Clinical Journal of Pain”

Chronic scalp pain in trichodynia involves both body-wide and localized increased pain sensitivity.

research Analysis of Common Treatment Drugs and Allergen Sensitization in Hair Loss Patients

February 2025 in “Journal of Cosmetic Dermatology”

Patch testing is crucial to reduce allergic reactions in hair loss treatments.

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Community Join

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community After quitting min and fin I asked AI on how fix the mess I am in and it says:

in Technology 1 year ago

Prolonged use of topical minoxidil and finasteride can lead to neuroendocrine and autonomic dysfunction, causing severe sensitivity and side effects. Recovery involves avoiding these treatments, supporting neurosteroid recovery, calming the sympathetic system, and rebuilding scalp health naturally.

community Quit finasteride after 15+ years

in Update 974 upvotes 1 year ago

A user stopped finasteride after 15 years due to severe side effects, which improved after quitting. They maintained most of their hair and are considering alternatives like topical treatments or RU58841.

community Dht kills hair, but no one says why?

in Finasteride/Dutasteride 40 upvotes 10 months ago

DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

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learn Thymosin Beta 4

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