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research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.
LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.
research Upregulation of mir-1199-5p is associated with reduced type 2 5-α reductase expression in benign prostatic hyperplasia
Higher levels of miR-1199-5p may reduce the effectiveness of certain prostate treatments.
research The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia
Finasteride effectively reduces hair loss by decreasing androgen levels.
research The effect of finasteride on the male rat brain
Finasteride affects the male rat brain by reducing certain protein activation, but these effects may reverse after stopping the drug.
research The Biomolecular Effects of Finasteride on Male Rat Brain during Administration and after Discontinuation
Finasteride temporarily suppresses brain activity, but some effects last even after stopping.
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5 / 1000+ resultscommunity 5ar Type I in the frontal hair follicles - Dutasteride
The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.
community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?
Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.
community 5 months on oral min and fin. Im 23 years old.
User experienced hair regrowth after 5 months on oral minoxidil and finasteride. Others praised the impressive results and mentioned the importance of combining treatments for best results.
community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.
Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.
community One year on dut 5mg daily as a 19-20 yr old , answering any queries
A 19-20-year-old has been using 0.5 mg of dutasteride daily for a year to combat hair loss, avoiding minoxidil due to side effects. They plan to continue this regimen and consider a future hair transplant, experiencing no significant side effects from dutasteride.