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GlossarySkin Carcinogenesis

Skin carcinogenesis refers to the process by which normal skin cells undergo malignant transformation, leading to the development of skin cancer. This process is often influenced by factors such as UV radiation, chemical exposure, and genetic predispositions. In the context of hair loss, certain skin cancers can affect the scalp and hair follicles, potentially leading to hair thinning or loss. Key distinguishing characteristics include the type of skin cancer (e.g., melanoma, basal cell carcinoma, squamous cell carcinoma) and the mechanisms of tumor development, which can vary significantly among different skin cancer types.

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Research

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research Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice

48 citations , June 2000 in “Japanese Journal of Cancer Research”

Dimethylarsinic acid speeds up skin tumor growth in certain mice.

research Lgr5+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors

8 citations , July 2016 in “Oncotarget”

Lgr5+ stem cells do not cause skin tumors.

research Targeted disruption of Bcl‐x_L in mouse keratinocytes inhibits both UVB‐ and chemically induced skin carcinogenesis

36 citations , March 2009 in “Molecular Carcinogenesis”

Disrupting Bcl-xL in mice reduces skin cancer risk.

research Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis

21 citations , August 2007 in “Experimental Dermatology”

Overexpression of hurpin in mice leads to abnormal skin and higher skin cancer risk.

research Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors

7 citations , November 2016 in “Oncotarget”

UV exposure reduces Lgr6+ stem cells in mouse skin and they don't significantly contribute to skin cancer development.

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Community Join

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community My kotoconazole shampoo contain this

in Ketoconazole 4 months ago

The conversation discusses the safety and use of ketoconazole shampoo for hair loss, with mentions of zinc pyrithione and selenium sulfide. Users debate the safety of these ingredients, particularly zinc pyrithione, and share opinions on regulatory differences between Europe and the US.

community Does RU58841 potentially cause cancer?

in Research/Science 1 year ago

RU58841 may pose cancer risks due to its antiandrogen properties and lack of long-term safety data. Using it is considered a high-risk experiment with unknown potential for harm.

community Someone told me it is the increase in estradiol and estrogen from more free t that makes dht blockers work?

in Chat 4 months ago

Finasteride and its effects on hair loss, with discussions on the role of estradiol and estrogen. Users debate whether increased estrogen from DHT blockers contributes to hair regrowth, with concerns about potential side effects like chemical castration.

community Expectations control for SCUBE3

in Research/Science 21 upvotes 2 years ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

community Unexpected temple hair growth from GHK-Cu

in Update 26 upvotes 7 months ago

GHK-Cu injections led to unexpected temple hair growth for someone who had been using minoxidil and finasteride for over a decade. The user plans to continue using GHK-Cu and experiment with a DIY AHK-Cu serum.

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