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research Distinct fibroblast lineages determine dermal architecture in skin development and repair

1235 citations , December 2013 in “Nature”

Two fibroblast types shape skin structure and repair differently.

research SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

225 citations , April 2018 in “Journal of Investigative Dermatology”

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

research Vitamin D-dependent rickets type II. Defective induction of 25-hydroxyvitamin D3-24-hydroxylase by 1,25-dihydroxyvitamin D3 in cultured skin fibroblasts.

81 citations , March 1985 in “Journal of Clinical Investigation”

Measuring 24-OHase induction helps identify defects in vitamin D processing and predict treatment response.

research Alteration of Skin Properties with Autologous Dermal Fibroblasts

67 citations , May 2014 in “International Journal of Molecular Sciences”

Using your own skin cells can help repair aging skin and promote hair growth.

research The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes

11 citations , February 2022 in “Scientific Reports”

CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.

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community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.

in Minoxidil 10 upvotes 5 years ago

The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.

community So does oral minoxidil age your skin or not

in Minoxidil 44 upvotes 2 years ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

in Minoxidil 37 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 year ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)

in Technology 13 upvotes 10 months ago

Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.

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