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GlossarySkin Penetration

process by which substances pass through the outer skin layer

Skin penetration refers to the process by which substances pass through the outermost layer of the skin, known as the stratum corneum, to reach deeper layers. This is a critical concept in dermatology and pharmacology, as it influences the effectiveness of topical medications and skincare products. Factors such as molecular size, solubility, and the condition of the skin can affect how well a substance penetrates.

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Research

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research Penetration of drugs through skin, a complex rate-controlling membrane

211 citations , June 2012

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Measurement of Skin Permeation and Penetration of Nanoparticles for Their Safety Evaluation

research Measurement of Skin Permeation/Penetration of Nanoparticles for Their Safety Evaluation

67 citations , January 2012 in “Biological and Pharmaceutical Bulletin”

Nanoparticles don't penetrate intact skin but can enter through pores or damaged skin.

research Cyproterone acetate-loaded nanostructured lipid carriers: effect of particle size on skin penetration and follicular targeting

40 citations , March 2019 in “Pharmaceutical development and technology”

Smaller particles of the drug carrier penetrated skin better, with 300 nm size being best for targeting hair follicles.

Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In Vitro Human Skin Studies

research Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies

35 citations , January 2018 in “Skin pharmacology and physiology”

Nanoemulsion creams with certain enhancers can greatly increase caffeine delivery through skin.

Nobiletin-Loaded Composite Penetration Enhancer Vesicles Restore Normal miRNA Expression and Chief Defense Antioxidant Levels in Skin Cancer

research Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer

34 citations , October 2021 in “Scientific Reports”

Nobiletin-loaded vesicles effectively treat skin cancer by restoring normal miRNA and antioxidant levels.

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Community Join

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community What’s a good carrier for GHK-Cu or AHK-Cu peptides to penetrate skin?

in Product 10 upvotes 3 months ago

Copper peptides for hair loss, discussing carriers for skin penetration and recommending a product from Amazon.

community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?

in Finasteride/Dutasteride 35 upvotes 2 years ago

A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.

community Topical dutasteride significantly outperforms oral finasteride

in Research/Science 65 upvotes 10 months ago

Topical dutasteride 0.05% is reported to outperform oral finasteride with minimal side effects, but concerns about study bias exist due to company funding. Some users report mixed results with topical dutasteride, noting issues with skin penetration and systemic absorption.

community Self-Experiment - Topical Rapamycin or a-KB

in Treatment 4 upvotes 4 years ago

A user plans to create a DIY topical treatment for hair loss using Rapamycin, possibly combined with alpha-ketoglutaric acid (a-KG). They discuss the concentration and formulation process for Rapamycin, considering safety and skin penetration, and intend to apply it every other day to the scalp.

community Castor oil without using penetration enhancer after microneedling?

in Question 7 upvotes 8 years ago

The conversation is about whether castor oil can be effectively used alone after microneedling without a penetration enhancer like DMSO or ethanol. The user believes microneedling-induced wounds might be enough for absorption.

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