Search

for
Search:

Did you mean SMAD signaling?

GlossarySMAD signaling

cellular process transmitting signals from surface to nucleus

SMAD signaling, also known as the SMAD pathway, is a cellular process that transmits signals from the cell surface to the nucleus in response to transforming growth factor-beta (TGF-β) and related cytokines. This pathway involves SMAD proteins, which are activated by receptor kinases and then move into the nucleus to regulate gene expression. This signaling is crucial for various biological processes, including cell growth, differentiation, and development, and has implications in conditions like cancer and fibrosis.

Related Terms

Research

5 / 1000+ results

research Live imaging of Smad2/3 signaling in mouse skin wound healing

12 citations , September 2007 in “Wound repair and regeneration”

Smad2/3-dependent TGF-β signaling increases during wound healing.

Network Pharmacology and In Vivo Experimental Analysis for Validating the Antifibrotic Potential of Punica Granatum Leaves Against Skin Scleroderma: The Role of Oxidative Stress, Inflammation and TGF-β1/Snail 1/p-Smad 3 Signaling Pathway

research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

April 2026 in “Inflammopharmacology”

Punica granatum leaf extract may help treat skin fibrosis by reducing inflammation and oxidative stress.

research Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

11 citations , February 2018 in “Oncotarget”

Lower SMAD2/3 activation predicts more severe skin cancer.

Kaempferol Enhances Hair Growth by Regulating JAK3/STAT6 and TGF-β/Smad Signaling in Human Dermal Papilla Cells and a C57BL/6 Mouse Model

research Kaempferol enhances hair growth by regulating JAK3/STAT6 and TGF-β/Smad signaling in human dermal papilla cells and a C57BL/6 mousemodel

October 2025 in “Records of Natural Products”

Kaempferol promotes hair growth and could be a natural treatment for hair loss.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

View more "smad2 3 signaling" in research →

Community Join

1 / 1000+ results

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

in Research/Science 59 upvotes 4 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

View more "smad2 3 signaling" in community →